UNIGE document Scientific Article
previous document  unige:103800  next document
add to browser collection

Preoperative factors of apathy in subthalamic stimulated Parkinson disease: A PET study

Robert, Gabriel H.
Le Jeune, Florence
Lozachmeur, Clément
Drapier, Sophie
Dondaine, Thibault
Houvenaghel, Jean-François
Travers, David
show hidden authors show all authors [1 - 12]
Published in Neurology. 2014, vol. 83, no. 18, p. 1620-1626
Abstract Objective: The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. Methods: To resolve this issue, we set out to identify preoperative metabolic patterns and sociodemographic and clinical factors associated with increased apathy after STN-DBS. Forty-four patients with Parkinson disease were enrolled in this study. They all underwent STN-DBS. Metabolic activity was assessed with F-18 fluorodeoxyglucose PET 3 months before surgery. Apathy was assessed on the Apathy Evaluation Scale 3 months before and after STN-DBS. We controlled for preoperative age, levodopa therapy, and overall cognitive functions. Results: Increased apathy after STN-DBS was significantly associated with reduced preoperative metabolism within the right ventral striatum. None of the sociodemographic and clinical variables tested were associated with apathy after STN-DBS. Conclusions: Preoperative PET, but not sociodemographic or clinical factors, is associated with apathy after STN-DBS.
Full text
Article (Published version) (338 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Affective sciences
Neuroscience de l'émotion et dynamiques affectives (NEAD)
(ISO format)
ROBERT, Gabriel H. et al. Preoperative factors of apathy in subthalamic stimulated Parkinson disease: A PET study. In: Neurology, 2014, vol. 83, n° 18, p. 1620-1626. doi: 10.1212/WNL.0000000000000941 https://archive-ouverte.unige.ch/unige:103800

325 hits

0 download


Deposited on : 2018-04-24

Export document
Format :
Citation style :