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Title

Preoperative factors of apathy in subthalamic stimulated Parkinson disease: A PET study

Authors
Robert, Gabriel H.
Le Jeune, Florence
Lozachmeur, Clément
Drapier, Sophie
Dondaine, Thibault
Houvenaghel, Jean-François
Travers, David
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Published in Neurology. 2014, vol. 83, no. 18, p. 1620-1626
Abstract Objective: The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. Methods: To resolve this issue, we set out to identify preoperative metabolic patterns and sociodemographic and clinical factors associated with increased apathy after STN-DBS. Forty-four patients with Parkinson disease were enrolled in this study. They all underwent STN-DBS. Metabolic activity was assessed with F-18 fluorodeoxyglucose PET 3 months before surgery. Apathy was assessed on the Apathy Evaluation Scale 3 months before and after STN-DBS. We controlled for preoperative age, levodopa therapy, and overall cognitive functions. Results: Increased apathy after STN-DBS was significantly associated with reduced preoperative metabolism within the right ventral striatum. None of the sociodemographic and clinical variables tested were associated with apathy after STN-DBS. Conclusions: Preoperative PET, but not sociodemographic or clinical factors, is associated with apathy after STN-DBS.
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Structures
Research groups Affective sciences
Neuroscience de l'émotion et dynamiques affectives (NEAD)
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ROBERT, Gabriel H. et al. Preoperative factors of apathy in subthalamic stimulated Parkinson disease: A PET study. In: Neurology, 2014, vol. 83, n° 18, p. 1620-1626. https://archive-ouverte.unige.ch/unige:103800

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Deposited on : 2018-04-24

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