Dynamic presynaptic varicosities: a role in activity-dependent synaptogenesis

Muller, Dominique; Nikonenko, Irina

doi:10.1016/j.tins.2003.08.010

Scientific article

English

Dynamic presynaptic varicosities: a role in activity-dependent synaptogenesis

Contributors

Muller, Dominique; Nikonenko, Irina

Published in

Trends in neurosciences, vol. 26, no. 11, p. 573-575

Publication date

2003

Abstract

Recent developments in confocal imaging techniques have opened new avenues for investigating how synaptic networks evolve over time. These studies have revealed not only that synaptic structures are motile but also, most importantly, that a fraction of synapses undergo a continuous elimination and formation process, and that these mechanisms are markedly enhanced by activity. Turnover of dendritic spines was recently demonstrated in the somatosensory cortex upon sensory stimulation. De Paola et al. have now provided evidence for correlated remodelling of presynaptic structures. These results, together with others, indicate that activation of neuronal networks enhances dynamic mechanisms at both the presynaptic and the postsynaptic level, resulting in an increased turnover of synapses and, accordingly, a reorganization of synaptic circuitry.

Keywords

Animals
Dendrites/ physiology
Excitatory Amino Acids/ physiology
Mice
Mice, Transgenic
Nerve Net/ growth & development
Neural Pathways/ growth & development
Neuronal Plasticity/physiology
Neurons/physiology
Presynaptic Terminals/ physiology

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Citation (ISO format)

MULLER, Dominique, NIKONENKO, Irina. Dynamic presynaptic varicosities: a role in activity-dependent synaptogenesis. In: Trends in neurosciences, 2003, vol. 26, n° 11, p. 573–575. doi: 10.1016/j.tins.2003.08.010

Article

Identifiers

PID : unige:10366
DOI : 10.1016/j.tins.2003.08.010
PMID : 14585594

Additional URL for this publication

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0V-49H1MKM-2-3&_cdi=4872&_user=779890&_pii=S0166223603002868&_orig=search&_coverDate=11%2F30%2F2003&_sk=999739988&view=c&wchp=dGLbVtz-zSkzk&md5=9491d53b0d378b7a1562f953c18370a1&ie=/sdarticle.pdf

Journal ISSN

0166-2236

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Creation

06/08/2010 13:47:14

First validation

06/08/2010 13:47:14

Update

14/03/2023 15:59:02

Status update

14/03/2023 15:59:02

Last indexation

29/10/2024 16:31:49

Dynamic presynaptic varicosities: a role in activity-dependent synaptogenesis

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation