Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

Luescher, Christian; Huber, K. M.

doi:10.1016/j.neuron.2010.01.016

Scientific article

English

Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

Contributors

Luescher, Christian

; Huber, K. M.

Published in

Neuron, vol. 65, no. 4, p. 445-459

Publication date

2010

Abstract

Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the neocortex, hippocampus, midbrain, striatum, and cerebellum. Here we focus on mGluR-induced long-term synaptic depression (LTD) and review the literature that implicates Gp1 mGluRs in the plasticity of behavior, learning, and memory. Moreover, recent studies investigating the molecular mechanisms of mGluR-LTD have discovered links to mental retardation, autism, Alzheimer's disease, Parkinson's disease, and drug addiction. We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease.

Keywords

Animals
Brain/ physiology
Brain Diseases/physiopathology
Humans
Long-Term Synaptic Depression/ physiology
Nerve Net/physiology
Neural Pathways/physiology
Receptors, Metabotropic Glutamate/ physiology
Synapses/ physiology
Synaptic Transmission/physiology

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

UNIGE research groups

Mécanismes cellulaires de la dépendance et de l'addiction (520)

Citation (ISO format)

LUESCHER, Christian, HUBER, K. M. Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease. In: Neuron, 2010, vol. 65, n° 4, p. 445–459. doi: 10.1016/j.neuron.2010.01.016

Article

Identifiers

PID : unige:10345
DOI : 10.1016/j.neuron.2010.01.016
PMID : 20188650

Additional URL for this publication

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSS-4YG202D-4-1&_cdi=7054&_user=779890&_pii=S0896627310000413&_orig=search&_coverDate=02%2F25%2F2010&_sk=999349995&view=c&wchp=dGLbVlb-zSkzV&md5=f1e385553a478141f6d9f3690bb74f4a&ie=/sdarticle.pdf

Journal ISSN

0896-6273

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Creation

06/08/2010 13:47:06

First validation

06/08/2010 13:47:06

Update

14/10/2025 05:54:21

Status update

14/03/2023 15:58:54

Last indexation

02/11/2026 16:36:46

Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation