Doctoral thesis
English

Role of motor cortex in goal-directed forelimb movement

ContributorsMorandell, Karin
DirectorsHuber, Danielorcid
Defense date2017-12-08
Abstract

The generation of voluntary movements can be described as a sequence of neuronal processes, including decision making, motor planning and execution. How the motor cortex contributes to movement production is still debated. This thesis focuses on the role of two murine motor cortical subregions in forelimb movements: the caudal forelimb area (CFA) and rostral forelimb area (RFA). To causally link neuronal activity to behavior, we transiently silenced these regions while mice were performing a delayed two-choice joystick task. Both subregions were essential for choosing and executing movements, yet, choice and execution were sequentially processed. Interestingly, CFA showed a prevalent role in dexterous movements. Surprisingly, during the delay period only combined inactivation of CFA and RFA affected choice. Our findings suggest a sequential and partially distributed neural processing of choice and execution across different subregions of the motor cortex.

Keywords
  • Motor cortex
  • Mouse
  • Forelimb
  • Movement
  • Brain
  • Voluntary
  • Skilled
  • Digits
  • Joystick
  • Optogenetics
  • Transgenic
  • Laser
  • Choice
  • Decision
  • Delay
  • Planning
  • Execution
  • Sensation
  • Vibration
  • Vibrotactile
NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne
Funding
  • Autre - New York Stem Cell Foundation
Citation (ISO format)
MORANDELL, Karin. Role of motor cortex in goal-directed forelimb movement. Doctoral Thesis, 2017. doi: 10.13097/archive-ouverte/unige:103191
Main files (1)
Thesis
accessLevelRestricted
Identifiers
696views
7downloads

Technical informations

Creation23/02/2018 11:22:00
First validation23/02/2018 11:22:00
Update13/10/2025 19:15:36
Status update15/03/2023 08:01:03
Last indexation03/11/2025 16:11:27
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack