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Role of motor cortex in goal-directed forelimb movement

Defense Thèse de doctorat : Univ. Genève et Lausanne, 2017 - Neur. 216 - 2017/12/08
Abstract The generation of voluntary movements can be described as a sequence of neuronal processes, including decision making, motor planning and execution. How the motor cortex contributes to movement production is still debated. This thesis focuses on the role of two murine motor cortical subregions in forelimb movements: the caudal forelimb area (CFA) and rostral forelimb area (RFA). To causally link neuronal activity to behavior, we transiently silenced these regions while mice were performing a delayed two-choice joystick task. Both subregions were essential for choosing and executing movements, yet, choice and execution were sequentially processed. Interestingly, CFA showed a prevalent role in dexterous movements. Surprisingly, during the delay period only combined inactivation of CFA and RFA affected choice. Our findings suggest a sequential and partially distributed neural processing of choice and execution across different subregions of the motor cortex.
Keywords Motor cortexMouseForelimbMovementBrainVoluntarySkilledDigitsJoystickOptogeneticsTransgenicLaserChoiceDecisionDelayPlanningExecutionSensationVibrationVibrotactile
URN: urn:nbn:ch:unige-1031911
Note Thèse en Neurosciences des universités de Genève et de Lausanne
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Thesis (12.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Huber Daniel (neurosciences fondamentales) (914)
Projects FNS: Swiss National Science Foundation
New York Stem Cell Foundation
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MORANDELL, Karin. Role of motor cortex in goal-directed forelimb movement. Université de Genève. Thèse, 2017. https://archive-ouverte.unige.ch/unige:103191

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Deposited on : 2018-03-26

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