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Scientific article
English

Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain

Published inCurrent Opinion in Biotechnology, vol. 49, p. 156-162
Publication date2018
Abstract

Proteins containing a SPX domain are involved in phosphate (Pi) homeostasis, including Pi transport and adaptation to Pi deficiency. The SPX domain harbors a basic surface binding Pi at low affinity and inositol pyrophosphates (PP-InsPs) at high affinity. Genetic and biochemical studies revealed that PP-InsPs serve as ligands for the SPX domain. Residues in the PHO1 SPX domain involved in PP-InsPs binding are critical for its Pi export activity, and the interaction between SPX proteins and the PHR1 transcription factor, which results in PHR1 inactivation, is promoted by PP-InsPs. Changes in PP-InsPs levels in response to Pi deficiency may thus contribute to the adaptation of plants to stress via the modulation of the activity of SPX-containing proteins and their interactors. Modulating PP-InsP levels or the affinity/specificity of the SPX domain for PP-InsP could potentially be used to engineer crops to maintain high yield under reduced Pi fertilizer input.

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Citation (ISO format)
JUNG, Ji-Yul et al. Control of plant phosphate homeostasis by inositol pyrophosphates and the SPX domain. In: Current Opinion in Biotechnology, 2018, vol. 49, p. 156–162. doi: 10.1016/j.copbio.2017.08.012
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ISSN of the journal0958-1669
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Creation03/20/2018 7:05:00 PM
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