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Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting

Plissonneau, Marie
Pansieri, Jonathan
Heinrich-Balard, Laurence
Morfin, Jean-François
Rivory, Pascaline
Mowat, Pierre
Dumoulin, Mireille
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Published in Journal of Nanobiotechnology. 2016, vol. 14, no. 1
Abstract Amyloidoses are characterized by the extracellular deposition of insoluble fibrillar proteinaceous aggregates highly organized into cross-β structure and referred to as amyloid fibrils. Nowadays, the diagnosis of these diseases remains tedious and involves multiple examinations while an early and accurate protein typing is crucial for the patients’ treatment. Routinely used neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) using Pittsburgh compound B, [11C]PIB, provide structural information and allow to assess the amyloid burden, respectively, but cannot discriminate between different amyloid deposits. Therefore, the availability of efficient multimodal imaging nanoparticles targeting specific amyloid fibrils would provide a minimally-invasive imaging tool useful for amyloidoses typing and early diagnosis. In the present study, we have functionalized gadolinium-based MRI nanoparticles (AGuIX) with peptides highly specific for Aβ amyloid fibrils, LPFFD and KLVFF. The capacity of such nanoparticles grafted with peptide to discriminate among different amyloid proteins, was tested with Aβ(1–42) fibrils and with mutated-(V30M) transthyretin (TTR) fibrils.
Keywords Beta-amyloidFibrilsMRIContrast agentGadolinium based nanoparticlesAmyloid imagingPeptide-targetingAlzheimer’s disease
PMID: 27455834
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Article (Published version) (1.9 MB) - public document Free access
Research group Technologie pharmaceutique
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PLISSONNEAU, Marie et al. Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting. In: Journal of Nanobiotechnology, 2016, vol. 14, n° 1. https://archive-ouverte.unige.ch/unige:103064

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Deposited on : 2018-03-21

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