Scientific article

Oxytocin excites neurons located in the ventromedial nucleus of the Guinea-pig hypothalamus

Published inJournal of neuroendocrinology, vol. 3, no. 5, p. 569-573
Publication date1991

Abstract The area of the ventromedial nucleus of the hypothalamus in the guinea-pig was shown in autoradiographs to contain high affinity binding sites for oxytocin. In order to ascertain whether these sites may represent neuronal receptors, single-cell extracellular recordings were obtained from ventromedial neurons in coronal slices of the hypothalamus of adult guinea-pigs. Oxytocin applied in the nanomolar range excited about half of the neurons tested; none were inhibited. The response to the peptide was reversible and concentration-dependent. It was exerted directly since it persisted under the condition of synaptic isolation. Moreover, the effect was specific since it could be mimicked by a selective oxytocin agonist and since vasopressin was usually at least 10-fold weaker than oxytocin. These findings suggest that the binding sites for oxytocin detected by light microscopic autoradiography in the guinea-pig hypothalamic ventromedial nucleus represent functional receptors.

Citation (ISO format)
INENAGA, K. et al. Oxytocin excites neurons located in the ventromedial nucleus of the Guinea-pig hypothalamus. In: Journal of neuroendocrinology, 1991, vol. 3, n° 5, p. 569–573. doi: 10.1111/j.1365-2826.1991.tb00318.x
Main files (1)
ISSN of the journal0953-8194

Technical informations

Creation08/06/2010 1:46:46 PM
First validation08/06/2010 1:46:46 PM
Update time03/14/2023 3:58:39 PM
Status update03/14/2023 3:58:39 PM
Last indexation02/12/2024 7:03:56 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack