

Other version: http://www3.interscience.wiley.com/journal/119359005/abstract
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Oxytocin excites neurons located in the ventromedial nucleus of the Guinea-pig hypothalamus |
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Published in | Journal of Neuroendocrinology. 1991, vol. 3, no. 5, p. 569-573 | |
Abstract | Abstract The area of the ventromedial nucleus of the hypothalamus in the guinea-pig was shown in autoradiographs to contain high affinity binding sites for oxytocin. In order to ascertain whether these sites may represent neuronal receptors, single-cell extracellular recordings were obtained from ventromedial neurons in coronal slices of the hypothalamus of adult guinea-pigs. Oxytocin applied in the nanomolar range excited about half of the neurons tested; none were inhibited. The response to the peptide was reversible and concentration-dependent. It was exerted directly since it persisted under the condition of synaptic isolation. Moreover, the effect was specific since it could be mimicked by a selective oxytocin agonist and since vasopressin was usually at least 10-fold weaker than oxytocin. These findings suggest that the binding sites for oxytocin detected by light microscopic autoradiography in the guinea-pig hypothalamic ventromedial nucleus represent functional receptors. | |
Identifiers | PMID: 19215507 | |
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![]() ![]() Other version: http://www3.interscience.wiley.com/journal/119359005/abstract |
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Citation (ISO format) | INENAGA, K. et al. Oxytocin excites neurons located in the ventromedial nucleus of the Guinea-pig hypothalamus. In: Journal of Neuroendocrinology, 1991, vol. 3, n° 5, p. 569-573. https://archive-ouverte.unige.ch/unige:10305 |