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Oxytocin excites neurons located in the ventromedial nucleus of the Guinea-pig hypothalamus

Inenaga, K.
Karman, H.
Yamashita, H.
Dreifuss, Jean-Jacques
Published in Journal of Neuroendocrinology. 1991, vol. 3, no. 5, p. 569-573
Abstract Abstract The area of the ventromedial nucleus of the hypothalamus in the guinea-pig was shown in autoradiographs to contain high affinity binding sites for oxytocin. In order to ascertain whether these sites may represent neuronal receptors, single-cell extracellular recordings were obtained from ventromedial neurons in coronal slices of the hypothalamus of adult guinea-pigs. Oxytocin applied in the nanomolar range excited about half of the neurons tested; none were inhibited. The response to the peptide was reversible and concentration-dependent. It was exerted directly since it persisted under the condition of synaptic isolation. Moreover, the effect was specific since it could be mimicked by a selective oxytocin agonist and since vasopressin was usually at least 10-fold weaker than oxytocin. These findings suggest that the binding sites for oxytocin detected by light microscopic autoradiography in the guinea-pig hypothalamic ventromedial nucleus represent functional receptors.
PMID: 19215507
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INENAGA, K. et al. Oxytocin excites neurons located in the ventromedial nucleus of the Guinea-pig hypothalamus. In: Journal of Neuroendocrinology, 1991, vol. 3, n° 5, p. 569-573. doi: 10.1111/j.1365-2826.1991.tb00318.x https://archive-ouverte.unige.ch/unige:10305

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Deposited on : 2010-08-06

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