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The distribution of MICA alleles in an Austrian population: evidence for increasing polymorphism

Wenda, Sabine
Faé, Ingrid
Mayr, Wolfgang R
Fischer, Gottfried F
Published in Human immunology. 2013, vol. 74, no. 10, p. 1295-1299
Abstract The Major Histocompatibility Complex Class I Chain-Related Gene A (MICA) is located 46.4 Kb centromeric to HLA-B locus on chromosome 6; 84 alleles have been described so far. To assess the distribution of MICA alleles in an Austrian population, 322 unrelated Austrian blood donors have been typed for MICA by direct sequencing of amplified exons 2-5; sequencing of exon 6 and separating alleles by haplotype specific primers or by cloning was performed to resolve ambiguities. HLA-B was typed at low level resolution and linkage disequilibrium was determined. We observed 20 already known and four novel MICA alleles. MICA*008:01/04 was the most frequent allele (42%), followed by MICA*002:01 (11%) and MICA*009:01 (9%), three alleles (MICA*029, *067 and *068) were observed only once. No deviation from the Hardy Weinberg equilibrium was observed. Linkage disequilibrium between MICA and HLA-B alleles was observed, most extensively between MICA*008:01/04 and HLA-B*07. Our population data are in agreement with other European populations. The fact that four novel alleles have been observed indicates that the polymorphism of MICA is larger than currently estimated.
Keywords AdolescentAdultAllelesAustraliaFemaleGene FrequencyGeneticsPopulationHaplotypesHistocompatibility Antigens Class I/geneticsHistocompatibility TestingHumansLinkage DisequilibriumMaleMiddle AgedPolymorphismGeneticYoung Adult
PMID: 23777932
Full text
Research groups Groupe Sanchez-Mazas
Unité d'anthropologie
Autre: COST Action BM0803 HLA-NET
(ISO format)
WENDA, Sabine et al. The distribution of MICA alleles in an Austrian population: evidence for increasing polymorphism. In: Human Immunology, 2013, vol. 74, n° 10, p. 1295-1299. doi: 10.1016/j.humimm.2013.06.013 https://archive-ouverte.unige.ch/unige:102921

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Deposited on : 2018-03-13

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