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Scientific article
English

The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation

Published inThe Journal of neuroscience, vol. 25, no. 16, p. 4127-4130
Publication date2005
Abstract

Sleep deprivation is accompanied by the progressive development of an irresistible need to sleep, a phenomenon whose mechanism has remained elusive. Here, we identified for the first time a reflection of that phenomenon in vitro by showing that, after a short 2 h period of total sleep deprivation, the action of noradrenaline on the wake-promoting hypocretin/orexin neurons changes from an excitation to an inhibition. We propose that such a conspicuous modification of responsiveness should contribute to the growing sleepiness that accompanies sleep deprivation.

Keywords
  • Animals
  • Blotting, Northern/methods
  • Electric Stimulation/methods
  • Hypothalamus/ pathology
  • Immunohistochemistry/methods
  • Intracellular Signaling Peptides and Proteins/ metabolism
  • Membrane Potentials/drug effects/physiology/radiation effects
  • Neurons/ drug effects/physiology
  • Neuropeptides/ metabolism
  • Norepinephrine/ pharmacology
  • Patch-Clamp Techniques/methods
  • RNA, Messenger/biosynthesis
  • Rats
  • Rats, Sprague-Dawley
  • Reverse Transcriptase Polymerase Chain Reaction/methods
  • Sleep Deprivation/pathology/ physiopathology
  • Wakefulness/ drug effects/physiology
Citation (ISO format)
GRIVEL, Jérémy et al. The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation. In: The Journal of neuroscience, 2005, vol. 25, n° 16, p. 4127–4130. doi: 10.1523/JNEUROSCI.0666-05.2005
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ISSN of the journal0270-6474
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