The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation

Grivel, Jérémy; Cvetkovic, Vesna; Bayer, Laurence; Machard, Daniele; Tobler, Irene; Muhlethaler, Michel; Serafin, Mauro

doi:10.1523/JNEUROSCI.0666-05.2005

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Title		The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation
Authors		Grivel, Jérémy Cvetkovic, Vesna Bayer, Laurence Machard, Daniele Tobler, Irene Muhlethaler, Michel Serafin, Mauro
Published in		Journal of Neuroscience. 2005, vol. 25, no. 16, p. 4127-4130
Abstract		Sleep deprivation is accompanied by the progressive development of an irresistible need to sleep, a phenomenon whose mechanism has remained elusive. Here, we identified for the first time a reflection of that phenomenon in vitro by showing that, after a short 2 h period of total sleep deprivation, the action of noradrenaline on the wake-promoting hypocretin/orexin neurons changes from an excitation to an inhibition. We propose that such a conspicuous modification of responsiveness should contribute to the growing sleepiness that accompanies sleep deprivation.
Keywords		Animals — Blotting, Northern/methods — Electric Stimulation/methods — Hypothalamus/ pathology — Immunohistochemistry/methods — Intracellular Signaling Peptides and Proteins/ metabolism — Membrane Potentials/drug effects/physiology/radiation effects — Neurons/ drug effects/physiology — Neuropeptides/ metabolism — Norepinephrine/ pharmacology — Patch-Clamp Techniques/methods — RNA, Messenger/biosynthesis — Rats — Rats, Sprague-Dawley — Reverse Transcriptase Polymerase Chain Reaction/methods — Sleep Deprivation/pathology/ physiopathology — Wakefulness/ drug effects/physiology
Identifiers		DOI: 10.1523/JNEUROSCI.0666-05.2005 PMID: 15843615
Full text		Article - Limited access to UNIGE Other version: http://www.jneurosci.org/cgi/reprint/25/16/4127.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation (ISO format)		GRIVEL, Jérémy et al. The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation. In: Journal of Neuroscience, 2005, vol. 25, n° 16, p. 4127-4130. doi: 10.1523/JNEUROSCI.0666-05.2005 https://archive-ouverte.unige.ch/unige:10292