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Scientific article
English

HLA-A-B-C-DRB1-DQB1 phased haplotypes in 124 Nigerian families indicate extreme HLA diversity and low linkage disequilibrium in Central-West Africa

Published inTissue Antigens, vol. 86, no. 4, p. 285-292
Publication date2015
Abstract

The simultaneous typing of five-HLA loci at high resolution and the availability of pedigree data allowed us to characterize extended five-locus phased haplotypes in 124 Nigerian families and to compare the observed frequencies with those expected by an expectation-maximization algorithm for unphased data. Despite the occurrence of some frequent alleles at each locus (e.g. B*53:01, which is assumed to protect against Plasmodium falciparum), as many as 82% of the sampled individuals carry two unique five-locus haplotypes and only three extended haplotypes with frequency above 1% exhibit significant linkage disequilibrium. Although preliminary, these results reveal an extreme level of HLA diversity in the Nigerian population, which reflects both its multi-ethnic composition and the very ancient demographic history of African populations.

Keywords
  • Alleles
  • Family
  • Gene Expression
  • Gene Frequency
  • Genetic Variation
  • Genetics
  • Population
  • HLA-A Antigens/genetics/immunology
  • HLA-B Antigens/genetics/immunology
  • HLA-C Antigens/genetics/immunology
  • HLA-DQ beta-Chains/genetics/immunology
  • HLA-DRB1 Chains/genetics/immunology
  • Haplotypes
  • Histocompatibility Testing
  • Humans
  • Linkage Disequilibrium
  • Nigeria
  • Pedigree
Citation (ISO format)
TESTI, M et al. HLA-A-B-C-DRB1-DQB1 phased haplotypes in 124 Nigerian families indicate extreme HLA diversity and low linkage disequilibrium in Central-West Africa. In: Tissue Antigens, 2015, vol. 86, n° 4, p. 285–292. doi: 10.1111/tan.12642
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Article (Published version)
accessLevelRestricted
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ISSN of the journal0001-2815
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