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Title

HLA-A-B-C-DRB1-DQB1 phased haplotypes in 124 Nigerian families indicate extreme HLA diversity and low linkage disequilibrium in Central-West Africa

Authors
Testi, M
Battarra, M
Lucarelli, G
Isgro, A
Morrone, A
Akinyanju, O
Wakama, T
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Published in Tissue Antigens. 2015, vol. 86, no. 4, p. 285-292
Abstract The simultaneous typing of five-HLA loci at high resolution and the availability of pedigree data allowed us to characterize extended five-locus phased haplotypes in 124 Nigerian families and to compare the observed frequencies with those expected by an expectation-maximization algorithm for unphased data. Despite the occurrence of some frequent alleles at each locus (e.g. B*53:01, which is assumed to protect against Plasmodium falciparum), as many as 82% of the sampled individuals carry two unique five-locus haplotypes and only three extended haplotypes with frequency above 1% exhibit significant linkage disequilibrium. Although preliminary, these results reveal an extreme level of HLA diversity in the Nigerian population, which reflects both its multi-ethnic composition and the very ancient demographic history of African populations.
Keywords AllelesFamilyGene ExpressionGene FrequencyGenetic VariationGeneticsPopulationHLA-A Antigens/genetics/immunologyHLA-B Antigens/genetics/immunologyHLA-C Antigens/genetics/immunologyHLA-DQ beta-Chains/genetics/immunologyHLA-DRB1 Chains/genetics/immunologyHaplotypesHistocompatibility TestingHumansLinkage DisequilibriumNigeriaPedigree
Identifiers
PMID: 26300115
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Research groups Unité d'anthropologie
Groupe Sanchez-Mazas
Project FNS: 31003A_144180
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(ISO format)
TESTI, M et al. HLA-A-B-C-DRB1-DQB1 phased haplotypes in 124 Nigerian families indicate extreme HLA diversity and low linkage disequilibrium in Central-West Africa. In: Tissue Antigens, 2015, vol. 86, n° 4, p. 285-292. https://archive-ouverte.unige.ch/unige:102917

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Deposited on : 2018-03-13

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