UNIGE document Scientific Article
previous document  unige:102916  next document
add to browser collection
Title

Mapping the HLA diversity of the Iberian Peninsula

Authors
Romòn, Iñigo
Montes, Carmen
Ligeiro, Dario
Trindade, Hélder
Published in Human Immunology. 2016, vol. 77, no. 10, p. 832-840
Abstract The polymorphism of HLA genes can be used to reconstruct human peopling history. However, this huge diversity impairs successful matching in stem cell transplantation, a situation which has led to the recruitment of millions of donors worldwide. In parallel to the increase of recruitment, registries are progressively relying on information from population genetics to optimize their donor pools in terms of HLA variability. In this study, the HLA data of 65,000 Spanish bone marrow donors were analyzed together with 60,000 Portuguese individuals to provide a comprehensive HLA genetic map of the Iberian Peninsula. The frequencies of many alleles were shown to vary continuously across the Peninsula, either increasing or decreasing from the Mediterranean coast to the Atlantic domain or from the Strait of Gibraltar to the Pyrenees and Bay of Biscay. Similar patterns were observed for several haplotypes. In addition, within some regions neighboring provinces share a close genetic similarity. These results outline the genetic landscape of the Iberian Peninsula, and confirm that the analysis of the HLA polymorphism may reveal relevant signatures of past demographic events even when data from donor registries are used. This conclusion stimulates future developments of the Spanish registry, presented here for the first time.
Keywords Gene FrequencyGenotypeHLA Antigens/geneticsHematopoietic Stem Cell TransplantationHistocompatibility TestingHumansPolymorphismGeneticRegistriesSpainTissue Donors
Identifiers
PMID: 27377016
Full text
Structures
Research groups Unité d'anthropologie
Groupe Sanchez-Mazas
Project FNS: 31003A_144180
Citation
(ISO format)
ROMÒN, Iñigo et al. Mapping the HLA diversity of the Iberian Peninsula. In: Human Immunology, 2016, vol. 77, n° 10, p. 832-840. https://archive-ouverte.unige.ch/unige:102916

27 hits

0 download

Update

Deposited on : 2018-03-13

Export document
Format :
Citation style :