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Long-term rearrangements of hippocampal mossy fiber terminal connectivity in the adult regulated by experience
|Published in||Neuron. 2006, vol. 50, no. 5, p. 749-763|
|Abstract||We investigated rearrangements of connectivity between hippocampal mossy fibers and CA3 pyramidal neurons. We found that mossy fibers establish 10-15 local terminal arborization complexes (LMT-Cs) in CA3, which exhibit major differences in size and divergence in adult mice. LMT-Cs exhibited two types of long-term rearrangements in connectivity in the adult: progressive expansion of LMT-C subsets along individual dendrites throughout life, and pronounced increases in LMT-C complexities in response to an enriched environment. In organotypic slice cultures, subsets of LMT-Cs also rearranged extensively and grew over weeks and months, altering the strength of preexisting connectivity, and establishing or dismantling connections with pyramidal neurons. Differences in LMT-C plasticity reflected properties of individual LMT-Cs, not mossy fibers. LMT-C maintenance and growth were regulated by spiking activity, mGluR2-sensitive transmitter release from LMTs, and PKC. Thus, subsets of terminal arborization complexes by mossy fibers rearrange their local connectivities in response to experience and age throughout life.|
|Keywords||Age Factors — Animals — Dendrites/physiology — Housing, Animal — Long-Term Potentiation/physiology — Mice — Mice, Inbred BALB C — Mice, Inbred C57BL — Mice, Transgenic — Nerve Fibers/ physiology — Neural Pathways/ physiology — Neuronal Plasticity/ physiology — Organ Culture Techniques — Pyramidal Cells/ cytology|