UNIGE document Scientific Article
previous document  unige:102780  next document
add to browser collection

Early alterations of social brain networks in young children with autism

Coito, Ana
show hidden authors show all authors [1 - 11]
Published in eLife. 2018, vol. 7, e31670
Abstract Social impairments are a hallmark of Autism Spectrum Disorders (ASD), but empirical evidence for early brain network alterations in response to social stimuli is scant in ASD. We recorded the gaze patterns and brain activity of toddlers with ASD and their typically developing peers while they explored dynamic social scenes. Directed functional connectivity analyses based on electrical source imaging revealed frequency specific network atypicalities in the theta and alpha frequency bands, manifesting as alterations in both the driving and the connections from key nodes of the social brain associated with autism. Analyses of brain-behavioural relationships within the ASD group suggested that compensatory mechanisms from dorsomedial frontal, inferior temporal and insular cortical regions were associated with less atypical gaze patterns and lower clinical impairment. Our results provide strong evidence that directed functional connectivity alterations of social brain networks is a core component of atypical brain development at early stages of ASD.
PMID: 29482718
Full text
Article (Published version) (3.9 MB) - public document Free access
Research groups Autism Brain and Behavior Lab (1033)
Epilepsie et réseaux cérébraux (1002)
Laboratoire d'imagerie et de psychopathologie développementale (693)
Organisation et plasticité des réseaux neuronaux cérébraux (148)
(ISO format)
SPERDIN, Holger Franz et al. Early alterations of social brain networks in young children with autism. In: eLife, 2018, vol. 7, p. e31670. doi: 10.7554/eLife.31670 https://archive-ouverte.unige.ch/unige:102780

492 hits



Deposited on : 2018-03-07

Export document
Format :
Citation style :