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Scientific article
English

Effects of prolonged bed rest on cardiovascular oxygen transport during submaximal exercise in humans

Contributors

Ferretti, Guido; Girardis, M.; Moia, Christian; Antonutto, G.

Published in

European journal of applied physiology and occupational physiology, vol. 78, no. 5, p. 398-402

Publication date

1998

Abstract

The hypothesis was tested that prolonged bed rest impairs O2 transport during exercise, which implies a lowering of cardiac output Qc and O2 delivery (QaO2). The following parameters were determined in five males at rest and at the steady-state of the 100-W exercise before (B) and after (A) 42-day bed rest with head-down tilt at -6 degrees: O2 consumption (VO2), by a standard open-circuit method; Qc, by the pressure pulse contour method, heart rate (fc), stroke volume (Qh), arterial O2 saturation, blood haemoglobin concentration ([Hb]), arterial O2 concentration (CaO2), and QaO2. The VO2 was the same in A and in B, as was the resting fc. The fc at 100 W was higher in A than in B (+17.5%). The Qh was markedly reduced (-27.7% and -22.2% at rest and 100 W, respectively). The Qc was lower in A than in B [-27.6% and -7.8% (NS) at rest and 100 W, respectively]. The CaO2 was lower in A than in B because of the reduction in [Hb]. Thus also QaO2 was lower in A than in B (-32.0% and -11.9% at rest and at 100 W, respectively). The present results would suggest a down-regulation of the O2 transport system after bed rest.

Keywords

  • Adult
  • Bed Rest
  • Blood Gas Analysis
  • Cardiac Output/ physiology
  • Humans
  • Male
  • Oxygen/ blood
  • Physical Exertion/ physiology
  • Tilt-Table Test
  • Time Factors

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

FERRETTI, Guido et al. Effects of prolonged bed rest on cardiovascular oxygen transport during submaximal exercise in humans. In: European journal of applied physiology and occupational physiology, 1998, vol. 78, n° 5, p. 398–402. doi: 10.1007/s004210050437

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Additional URL for this publication

http://www.springerlink.com/content/76npjn92qad13lp7/fulltext.pdf

Journal ISSN

0301-5548
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Creation

06/08/2010 13:46:28

First validation

06/08/2010 13:46:28

Update

14/03/2023 15:58:22

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14/03/2023 15:58:22

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