Doctoral thesis

The Role of TOR Complex 2 in the Maintenance of Plasma Membrane Tension Homeostasis

ContributorsRiggi, Margot
Defense date2017-12-18

Constant changes in the environment constitute a threat for the maintenance of the homeostasis of an organism, and require all uni- or multicellular species to adapt in order to survive and prosper. The two multiprotein TOR Complexes, both nucleated around the conserved Target Of Rapamycin kinase, are now broadly considered as major regulators of eukaryotic cellular growth, serving as direct transducers of extracellular biotic and abiotic signals. On top of this traditional view, there is growing evidence that they also act as mediators of various aspects of cellular and organismal homeostasis. Specifically, TORC2 plays a key role in the maintenance of plasma membrane tensile homeostasis. Indeed, despite its established importance in the orchestration of many biological processes both at the cellular and tissue levels, little is known about the necessary mechanisms that regulate plasma membrane tension under ever-changing conditions due to extrinsic stressors or intrinsic phenomena such as growth. The general goal of this project was thus to investigate TORC2-mediated control of plasma membrane tension

Citation (ISO format)
RIGGI, Margot. The Role of TOR Complex 2 in the Maintenance of Plasma Membrane Tension Homeostasis. 2017. doi: 10.13097/archive-ouverte/unige:102521
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Creation01/23/2018 8:54:00 AM
First validation01/23/2018 8:54:00 AM
Update time03/15/2023 7:54:18 AM
Status update03/15/2023 7:54:17 AM
Last indexation10/19/2023 7:55:17 AM
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