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Title

Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?

Authors
Taylor, Walter
Published in Malaria Journal. 2006, vol. 5, p. 81
Abstract Artemisinin-containing therapies are highly effective against Plasmodium falciparum malaria. Insufficient numbers of tablets and inadequate package inserts result in sub-optimal dosing and possible treatment failure. This study reports the case of three, non-immune, expatriate workers with P. falciparum acquired in Africa, who failed to respond to artemisinin-based therapy. Sub-therapeutic dosing in accordance with the manufacturers' recommendations was the probable cause.
Keywords AdultAntimalarials/administration & dosage/therapeutic useArtemisinins/administration & dosage/therapeutic useCote d'IvoireDose-Response Relationship, DrugDrug Labeling/standardsEthanolamines/administration & dosage/therapeutic useFemaleFluorenes/administration & dosage/therapeutic useGuidelines as TopicGuineaHumansLactones/administration & dosage/therapeutic useMalaria, Falciparum/drug therapyParasitemia/drug therapyRecurrenceRiskSesquiterpenes/administration & dosage/therapeutic useSudanSwitzerland/ethnologyTreatment FailureWorld Health Organization
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PMID: 17020598
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JACKSON, Yves-Laurent Julien et al. Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?. In: Malaria Journal, 2006, vol. 5, p. 81. https://archive-ouverte.unige.ch/unige:102462

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Deposited on : 2018-02-21

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