Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?

Jackson, Yves-Laurent Julien; Chappuis, François; Loutan, Louis; Taylor, Walter

doi:10.1186/1475-2875-5-81

Scientific article

English

Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?

Contributors

Jackson, Yves-Laurent Julien

; Chappuis, François; Loutan, Louis; Taylor, Walter

Published in

Malaria Journal, vol. 5, 81

Publication date

2006

Abstract

Artemisinin-containing therapies are highly effective against Plasmodium falciparum malaria. Insufficient numbers of tablets and inadequate package inserts result in sub-optimal dosing and possible treatment failure. This study reports the case of three, non-immune, expatriate workers with P. falciparum acquired in Africa, who failed to respond to artemisinin-based therapy. Sub-therapeutic dosing in accordance with the manufacturers' recommendations was the probable cause.

Keywords

Adult
Antimalarials/administration & dosage/therapeutic use
Artemisinins/administration & dosage/therapeutic use
Cote d'Ivoire
Dose-Response Relationship, Drug
Drug Labeling/standards
Ethanolamines/administration & dosage/therapeutic use
Female
Fluorenes/administration & dosage/therapeutic use
Guidelines as Topic
Guinea
Humans
Lactones/administration & dosage/therapeutic use
Malaria, Falciparum/drug therapy
Parasitemia/drug therapy
Recurrence
Risk
Sesquiterpenes/administration & dosage/therapeutic use
Sudan
Switzerland/ethnology
Treatment Failure
World Health Organization

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de médecine de premier recours

Citation (ISO format)

JACKSON, Yves-Laurent Julien et al. Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure? In: Malaria Journal, 2006, vol. 5, p. 81. doi: 10.1186/1475-2875-5-81

Article (Published version)

CC BY

Identifiers

PID : unige:102462
DOI : 10.1186/1475-2875-5-81
PMID : 17020598

Journal ISSN

1475-2875

440views

376downloads

Creation

20/02/2018 15:34:00

First validation

20/02/2018 15:34:00

Update

15/03/2023 07:53:36

Status update

15/03/2023 07:53:35

Last indexation

31/10/2024 09:40:17

Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation