Article (Published version) (215 Kb) - Free access
Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?
|Published in||Malaria Journal. 2006, vol. 5, p. 81|
|Abstract||Artemisinin-containing therapies are highly effective against Plasmodium falciparum malaria. Insufficient numbers of tablets and inadequate package inserts result in sub-optimal dosing and possible treatment failure. This study reports the case of three, non-immune, expatriate workers with P. falciparum acquired in Africa, who failed to respond to artemisinin-based therapy. Sub-therapeutic dosing in accordance with the manufacturers' recommendations was the probable cause.|
|Keywords||Adult — Antimalarials/administration & dosage/therapeutic use — Artemisinins/administration & dosage/therapeutic use — Cote d'Ivoire — Dose-Response Relationship, Drug — Drug Labeling/standards — Ethanolamines/administration & dosage/therapeutic use — Female — Fluorenes/administration & dosage/therapeutic use — Guidelines as Topic — Guinea — Humans — Lactones/administration & dosage/therapeutic use — Malaria, Falciparum/drug therapy — Parasitemia/drug therapy — Recurrence — Risk — Sesquiterpenes/administration & dosage/therapeutic use — Sudan — Switzerland/ethnology — Treatment Failure — World Health Organization|
|JACKSON, Yves-Laurent Julien et al. Malaria treatment failures after artemisinin-based therapy in three expatriates: could improved manufacturer information help to decrease the risk of treatment failure?. In: Malaria Journal, 2006, vol. 5, p. 81. doi: 10.1186/1475-2875-5-81 https://archive-ouverte.unige.ch/unige:102462|