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Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice

Contributors

Bascuas Castillo, Thaïs; Moreno, María; Grille, Sofía; Chabalgoity, José A.

Published in

Frontiers in Immunology, vol. 9

Publication date

2018

Abstract

We have previously shown that Salmonella immunotherapy is effective to treat B-cell non-Hodgkin lymphoma (B-NHL) in mice. However, this model involves animals with high tumor burden, whereas in the clinics B-NHL patients are usually treated with chemotherapy (CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisone) as first-line therapy prior to immunotherapy. Recently, we have described a NHL-B preclinical model using CHOP chemotherapy to achieve MRD in immunocompetent animals that closely resemble patients' conditions. In this work, we assessed the efficacy of Salmonella immunotherapy in B-NHL-bearing mice undergoing chemotherapy. Salmonella administration significantly delayed tumor growth and prolonged survival of chemotherapy-treated NHL-bearing animals. Mice receiving the CHOP–Salmonella combined therapy showed increased numbers of tumor-infiltrating leukocytes and a different profile of cytokines and chemokines expressed in the tumor microenvironment. Further, Salmonella immunotherapy in CHOP-treated animals also enhanced NK cells cytotoxic activity as well as induced systemic lymphoma-specific humoral and cellular responses. Chemotherapy treatment profoundly impacted on the general health status of recipient animals, but those receiving Salmonella showed significantly better overall body condition. Altogether, the results clearly demonstrated that Salmonella immunotherapy could be safely used in individuals under CHOP treatment, resulting in a better prognosis. These results give strong support to consider Salmonella as a neoadjuvant therapy in a clinical setting.

Keywords

  • Non-Hodgkin lymphoma
  • Chemotherapy
  • CHOP
  • Salmonella
  • Immunotherapy

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

BASCUAS CASTILLO, Thaïs et al. Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice. In: Frontiers in Immunology, 2018, vol. 9. doi: 10.3389/fimmu.2018.00007

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Article (Published version)
CC BY

Identifiers

Journal ISSN

1664-3224
494views
268downloads

Technical informations

Creation

04/02/2018 16:46:00

First validation

04/02/2018 16:46:00

Update

15/03/2023 07:51:51

Status update

15/03/2023 07:51:50

Last indexation

31/10/2024 09:35:51
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