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A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

Kälin, Stefanie
Becker, Maike
CollaborationWith : Rohner-Jeanrenaud, Françoise
Published in Cell Metabolism. 2017, vol. 26, no. 3, p. 475-492.e7
Abstract Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3+ regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4+ T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss- and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3+ Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.
Keywords Borcs6C17orf59Foxp3PTENSTAT6T cellsTregsAdipose tissue functionCold exposureMetabolic functionMetabolismRegulatory T cells
PMID: 28877454
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KÄLIN, Stefanie, BECKER, Maike. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. In: Cell Metabolism, 2017, vol. 26, n° 3, p. 475-492.e7. doi: 10.1016/j.cmet.2017.08.008 https://archive-ouverte.unige.ch/unige:102011

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Deposited on : 2018-02-09

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