Scientific article

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

Published inCell Metabolism, vol. 26, no. 3, p. 475-492.e7
Publication date2017

Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3+ regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4+ T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss- and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3+ Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.

  • Borcs6
  • C17orf59
  • Foxp3
  • PTEN
  • STAT6
  • T cells
  • Tregs
  • Adipose tissue function
  • Cold exposure
  • Metabolic function
  • Metabolism
  • Regulatory T cells
Citation (ISO format)
KÄLIN, Stefanie, BECKER, Maike. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. In: Cell Metabolism, 2017, vol. 26, n° 3, p. 475–492.e7. doi: 10.1016/j.cmet.2017.08.008
Main files (1)
Article (Published version)
ISSN of the journal1550-4131

Technical informations

Creation02/08/2018 3:10:00 PM
First validation02/08/2018 3:10:00 PM
Update time03/15/2023 7:50:46 AM
Status update03/15/2023 7:50:45 AM
Last indexation01/17/2024 2:13:55 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack