UNIGE document Scientific Article
previous document  unige:10195  next document
add to browser collection

Excitatory action of hypocretin/orexin on neurons of the central medial amygdala

Bisetti, A.
Cvetkovic, V.
Machard, D.
Jones, B. E.
Published in Neuroscience. 2006, vol. 142, no. 4, p. 999-1004
Abstract The neurons of the lateral hypothalamus that contain hypocretin/orexin (hcrt/orx) are thought to promote arousal through the excitatory action they exert on the multiple areas to which they project within the CNS. We show here that the hcrt/orx peptides can also exert a strong action on the amygdala, a structure known for its implication in emotional aspects of behavior. Indeed, the hcrt/orx peptides, applied in acute rat brain slices, excite a specific class of "low threshold burst" neurons in the central medial (CeM) nucleus which is considered as a major output of the amygdala. These excitatory effects are postsynaptic, mediated by Hcrt2/OX2 receptors and result from the closure of a potassium conductance. They occur on a class of neurons that are also excited by vasopressin acting through V1a receptors. These results suggest that the hcrt/orx system can act through the amygdala to augment arousal and evoke the autonomic and behavioral responses associated with fear, stress or emotion.
Keywords Action Potentials/drug effects/physiologyAmygdala/drug effects/ metabolismAnimalsArousal/drug effects/physiologyExcitatory Postsynaptic Potentials/drug effects/ physiologyFear/drug effects/physiologyIntracellular Signaling Peptides and Proteins/ metabolism/pharmacologyNeural Pathways/drug effects/ metabolismNeurons/drug effects/ metabolismNeuropeptides/ metabolism/pharmacologyOrgan Culture TechniquesPotassium Channels/drug effects/metabolismRatsReceptors, G-Protein-Coupled/drug effects/metabolismReceptors, Neuropeptide/drug effects/metabolismReceptors, Vasopressin/agonists/metabolismStress, Psychological/metabolism/physiopathologySynaptic Transmission/drug effects/ physiologyVasopressins/metabolism/pharmacology
PMID: 16996221
Full text
(ISO format)
BISETTI, A. et al. Excitatory action of hypocretin/orexin on neurons of the central medial amygdala. In: Neuroscience, 2006, vol. 142, n° 4, p. 999-1004. doi: 10.1016/j.neuroscience.2006.07.018 https://archive-ouverte.unige.ch/unige:10195

472 hits

0 download


Deposited on : 2010-08-06

Export document
Format :
Citation style :