Impact of a product-specific reference standard for the measurement of a PEGylated rFVIII activity: the Swiss Multicentre Field Study

Bulla, O; Poncet, Antoine; Alberio, L; Asmis, L M; Gähler, A; Graf, L; Nagler, M; Studt, J-D; Tsakiris, D A; Fontana, Pierre

doi:10.1111/hae.13250

Scientific article

English

Impact of a product-specific reference standard for the measurement of a PEGylated rFVIII activity: the Swiss Multicentre Field Study

ContributorsBulla, O; Poncet, Antoine; Alberio, L; Asmis, L M; Gähler, A; Graf, L; Nagler, M; Studt, J-D; Tsakiris, D A; Fontana, Pierre

Published inHaemophilia, vol. 23, no. 4, p. e335-e339

Publication date2017

Abstract

Measuring factor VIII (FVIII) activity can be challenging when it has been modified, such as when FVIII is pegylated to increase its circulating half-life. Use of a product-specific reference standard may help avoid this issue.

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Citation (ISO format)

BULLA, O et al. Impact of a product-specific reference standard for the measurement of a PEGylated rFVIII activity: the Swiss Multicentre Field Study. In: Haemophilia, 2017, vol. 23, n° 4, p. e335–e339. doi: 10.1111/hae.13250

Article (Published version)

Identifiers

PID : unige:101835
DOI : 10.1111/hae.13250
PMID : 28544263

ISSN of the journal1351-8216

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Impact of a product-specific reference standard for the measurement of a PEGylated rFVIII activity: the Swiss Multicentre Field Study

Measuring factor VIII (FVIII) activity can be challenging when it has been modified, such as when FVIII is pegylated to increase its circulating half-life. Use of a product-specific reference standard may help avoid this issue.

Technical informations