Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials

Beyer-Westendorf, Jan; Lensing, Anthonie W A; Arya, Roopen; Bounameaux, Henri; Cohen, Alexander T; Wells, Philip S; Middeldorp, Saskia; Verhamme, Peter; Hughes, Rodney; Kucher, Nils; Pap, Akos F; Trajanovic, Mila; Prins, Martin H; Prandoni, Paolo; Weitz, Jeffrey I

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Title		Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials
Authors		Beyer-Westendorf, Jan Lensing, Anthonie W A Arya, Roopen Bounameaux, Henri Cohen, Alexander T Wells, Philip S Middeldorp, Saskia Verhamme, Peter Hughes, Rodney Kucher, Nils Pap, Akos F Trajanovic, Mila Prins, Martin H Prandoni, Paolo Weitz, Jeffrey I show all authors [1 - 15]
Published in		Thrombosis Research. 2017, vol. 149, p. 29-37
Abstract		The results of the EINSTEIN-DVT/PE and AMPLIFY trials, which compared rivaroxaban and apixaban with conventional anticoagulation therapy for acute venous thromboembolism (VTE), respectively, are often compared. However, the trials differed in duration of therapy (3-12 and 6months, respectively) and in patient selection (few exclusion criteria and more stringent exclusion criteria, respectively).
Keywords		Adult — Aged — Cohort Studies — Factor Xa Inhibitors/administration & dosage/adverse effects/therapeutic use — Female — Hemorrhage/chemically induced — Humans — Male — Middle Aged — Patient Selection — Pyrazoles/administration & dosage/adverse effects/therapeutic use — Pyridones/administration & dosage/adverse effects/therapeutic use — Rivaroxaban/administration & dosage/adverse effects/therapeutic use — Treatment Outcome — Venous Thromboembolism/drug therapy
Identifiers		DOI: 10.1016/j.thromres.2016.11.014 PMID: 27886530
Full text		Article (Published version) (699 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group		La maladie thromboembolique veineuse (808)
Citation (ISO format)		BEYER-WESTENDORF, Jan et al. Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials. In: Thrombosis Research, 2017, vol. 149, p. 29-37. https://archive-ouverte.unige.ch/unige:101427