Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials

Beyer-Westendorf, Jan; Lensing, Anthonie W A; Arya, Roopen; Bounameaux, Henri; Cohen, Alexander T; Wells, Philip S; Middeldorp, Saskia; Verhamme, Peter; Hughes, Rodney; Kucher, Nils; Pap, Akos F; Trajanovic, Mila; Prins, Martin H; Prandoni, Paolo; Weitz, Jeffrey I

doi:10.1016/j.thromres.2016.11.014

Scientific article

English

Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials

ContributorsBeyer-Westendorf, Jan; Lensing, Anthonie W A; Arya, Roopen; Bounameaux, Henri; Cohen, Alexander T; Wells, Philip S; Middeldorp, Saskia; Verhamme, Peter; Hughes, Rodney; Kucher, Nils; Pap, Akos F; Trajanovic, Mila; Prins, Martin H; Prandoni, Paolo; Weitz, Jeffrey I

Published inThrombosis Research, vol. 149, p. 29-37

Publication date2017

Abstract

The results of the EINSTEIN-DVT/PE and AMPLIFY trials, which compared rivaroxaban and apixaban with conventional anticoagulation therapy for acute venous thromboembolism (VTE), respectively, are often compared. However, the trials differed in duration of therapy (3-12 and 6months, respectively) and in patient selection (few exclusion criteria and more stringent exclusion criteria, respectively).

Keywords

Adult
Aged
Cohort Studies
Factor Xa Inhibitors/administration & dosage/adverse effects/therapeutic use
Female
Hemorrhage/chemically induced
Humans
Male
Middle Aged
Patient Selection
Pyrazoles/administration & dosage/adverse effects/therapeutic use
Pyridones/administration & dosage/adverse effects/therapeutic use
Rivaroxaban/administration & dosage/adverse effects/therapeutic use
Treatment Outcome
Venous Thromboembolism/drug therapy

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

La maladie thromboembolique veineuse (808)

Citation (ISO format)

BEYER-WESTENDORF, Jan et al. Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials. In: Thrombosis Research, 2017, vol. 149, p. 29–37. doi: 10.1016/j.thromres.2016.11.014

Article (Published version)

Identifiers

PID : unige:101427
DOI : 10.1016/j.thromres.2016.11.014
PMID : 27886530

ISSN of the journal0049-3848

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Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials

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