Functional neuronal binding sites for oxytocin in the ventromedial hypothalamus of the guinea pig after gonadectomy

Tribollet, Eliane; Li, Z.; Inenaga, K.; Yamashita, H.; Raggenbass, Mario; Dubois-Dauphin, Michel; Dreifuss, Jean-Jacques

doi:10.1016/0006-8993(92)91598-9

Scientific article

English

Functional neuronal binding sites for oxytocin in the ventromedial hypothalamus of the guinea pig after gonadectomy

Contributors

Tribollet, Eliane; Li, Z.; Inenaga, K.; Yamashita, H.; Raggenbass, Mario; Dubois-Dauphin, Michel; Dreifuss, Jean-Jacques

Published in

Brain research, vol. 588, no. 2, p. 346-350

Publication date

1992

Abstract

Castration in rats of either sex has been shown to markedly decrease hypothalamic oxytocin binding in the ventromedial hypothalamus and this can be reversed by injecting gonadal steroids. We wondered whether castration exerts similar effects on homologous oxytocin binding sites present in the guinea pig hypothalamus. Adult male guinea pigs were castrated and killed 2-90 days later. Binding sites for oxytocin in the ventromedial nucleus and neuronal responses to this peptide were little affected by gonadectomy, in contrast to what is observed in the rat under similar experimental conditions. The steroid dependency of hypothalamic oxytocin receptors appears therefore to be species dependent.

Keywords

Animals
Female
Guinea Pigs
Male
Neurons/ metabolism
Orchiectomy
Ovariectomy
Rats
Receptors, Angiotensin/ metabolism
Receptors, Oxytocin
Ventromedial Hypothalamic Nucleus/anatomy & histology/ metabolism

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Citation (ISO format)

TRIBOLLET, Eliane et al. Functional neuronal binding sites for oxytocin in the ventromedial hypothalamus of the guinea pig after gonadectomy. In: Brain research, 1992, vol. 588, n° 2, p. 346–350. doi: 10.1016/0006-8993(92)91598-9

Identifiers

PID : unige:10135
DOI : 10.1016/0006-8993(92)91598-9
PMID : 1327411

Journal ISSN

0006-8993

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Functional neuronal binding sites for oxytocin in the ventromedial hypothalamus of the guinea pig after gonadectomy

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation