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Bone morphogenetic protein use in spine surgery-complications and outcomes: a systematic review

Tournier, Clément
Garcia, Matthieu
Aunoble, Stéphane
Published in International Orthopaedics. 2016, vol. 40, no. 6, p. 1309-1319
Abstract Because of significant complications related to the use of autologous bone grafts in spinal fusion surgery, bone substitutes and growth factors such as bone morphogenetic protein (BMP) have been developed. One of them, recombinant human (rh) BMP-2, has been approved by the Food and Drug Administration (FDA) for use under precise conditions. However, rhBMP-2-related side effects have been reported, used in FDA-approved procedures, but also in off-label use.A systematic review of clinical data was conducted to analyse the rhBMP-2-related adverse events (AEs), in order to assess their prevalence and the associated surgery practices.
Keywords AdultBone Morphogenetic Protein 2/adverse effects/therapeutic useBone Transplantation/adverse effects/methodsFemaleHumansLow Back Pain/etiologyLumbar Vertebrae/surgeryMaleMiddle AgedOff-Label UsePostoperative Complications/epidemiologyRecombinant Proteins/adverse effects/therapeutic useSpinal Fusion/adverse effects/methodsTransforming Growth Factor beta/adverse effects/therapeutic use
PMID: 26961193
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Research group Thérapie cellulaire et troubles musculo-squelettiques (960)
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FAUNDEZ, Antonio et al. Bone morphogenetic protein use in spine surgery-complications and outcomes: a systematic review. In: International Orthopaedics, 2016, vol. 40, n° 6, p. 1309-1319. doi: 10.1007/s00264-016-3149-8 https://archive-ouverte.unige.ch/unige:101311

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Deposited on : 2018-01-10

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