Scientific article

Medial vestibular nucleus in the guinea-pig: histaminergic receptors. I. An in vitro study

Published inExperimental brain research, vol. 93, no. 2, p. 242-248
Publication date1993

Antihistaminergic drugs are currently used for the symptomatic treatment of vestibular-related syndromes such as vertigo and motion sickness. We therefore investigated whether histamine could modulate the firing of medial vestibular nuclei neurons (MVNn). Recently, we have demonstrated that different cell types are present among MVNn in guinea-pig brainstem slices. Bath-application of histamine at 10(-4) or 10(-5) M induced a small membrane depolarization accompanied by a slight decrease in membrane resistance and a reversible increase in spontaneous firing in all MVN cell types. These effects were presumably postsynaptic as they persisted in a low-calcium/high-magnesium solution. Using a variety of agonists and antagonists of histamine receptors (H1, H2 and H3), we conclude that these effects are mediated by H2 receptors. The companion paper is concerned with an in vivo study of the histaminergic modulation of the vestibular function (Yabe et al., in press).

  • Animals
  • Brain Stem/physiology
  • Cerebral Ventricles/physiology
  • Electrophysiology
  • Guinea Pigs
  • Histamine/pharmacology
  • Isoquinolines
  • Membrane Potentials/physiology
  • Neurons/physiology
  • Receptors, Histamine/ drug effects
  • Receptors, Histamine H1/drug effects
  • Receptors, Histamine H2/drug effects
  • Receptors, Histamine H3
  • Vestibular Nuclei/ physiology
Citation (ISO format)
SERAFIN, Mauro et al. Medial vestibular nucleus in the guinea-pig: histaminergic receptors. I. An in vitro study. In: Experimental brain research, 1993, vol. 93, n° 2, p. 242–248. doi: 10.1007/bf00228391
ISSN of the journal0014-4819

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