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Opiates inhibit pedunculopontine neurones in guinea pig brainstem slices

Khateb, A.
Published in Neuroscience Letters. 1990, vol. 119, no. 1, p. 125-128
Abstract Intracellular recordings were obtained from pedunculopontine neurones in guinea-pig brainstem slices. These cells were characterized by a broad action potential, an A-like conductance and fired spontaneously in a regular manner. These neurones were inhibited by bath-application of both carbachol and serotonine at concentrations of 10(-4) M. Opioid peptides induced a dose-dependent hyperpolarization and a reduction in the spontaneous firing. These latter effects could be blocked by the opiate antagonist naloxone and were direct as they persisted in presence of tetrodotoxine or high magnesium/low calcium-containing salines. They were mediated by an opiate receptor of the mu type since they were obtained with the mu-preferring enkephalin analogues FK 33-824 and DAGO, but neither with the delta nor the kappa analogues such as DPLPE or U-50,488.
Keywords AnimalsBrain Stem/cytology/ drug effects/physiologyD-Ala(2),MePhe(4),Met(0)-ol-enkephalin/pharmacologyDose-Response Relationship, DrugElectrophysiologyEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Enkephalins/pharmacologyGuinea PigsNarcotics/ pharmacologyNeural InhibitionNeurons/ drug effects/physiologyPons/cytology/ drug effects/physiology
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PMID: 2097575

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Deposited on : 2010-08-06

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