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Title

Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus
Authors
Muhlethaler, Michel
Charpak, S.
Dreifuss, Jean-Jacques
Published in Brain Research. 1984, vol. 308, no. 1, p. 97-107
Abstract Oxytocin and vasopressin increased the rate of firing of a class of presumed non-pyramidal neurones located in the CA1 area of rat hippocampal slices. This excitatory effect persisted in conditions of synaptic uncoupling. In contrast, pyramidal neurones were either unaffected by neurohypophysial peptides or showed one or several of the following effects: a decrease in firing rate in cells which were spontaneously active; a slight membrane hyperpolarization; and an increase in the rate of occurrence of spontaneous inhibitory postsynaptic potentials. We therefore propose that oxytocin and vasopressin excite directly a class of non-pyramidal inhibitory interneurones, whereas their observed effect on pyramidal neurones is indirect and inhibitory.
Keywords Action Potentials/drug effects — Animals — Arginine Vasopressin/ pharmacology — Electric Conductivity/drug effects — Electric Stimulation — Hippocampus/drug effects/ physiology — Membrane Potentials/drug effects — Neurons/drug effects/ physiology — Oxytocin/ pharmacology — Pyramidal Tracts/drug effects/ physiology — Rats
Identifiers
PMID: 6478205
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Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation
(ISO format) 		MUHLETHALER, Michel, CHARPAK, S., DREIFUSS, Jean-Jacques. Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus. In: Brain Research, 1984, vol. 308, n° 1, p. 97-107. https://archive-ouverte.unige.ch/unige:10097

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Deposited on : 2010-08-06

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