UNIGE document Scientific Article
previous document  unige:10097  next document
add to browser collection
Title

Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus

Authors
Charpak, S.
Dreifuss, Jean-Jacques
Published in Brain Research. 1984, vol. 308, no. 1, p. 97-107
Abstract Oxytocin and vasopressin increased the rate of firing of a class of presumed non-pyramidal neurones located in the CA1 area of rat hippocampal slices. This excitatory effect persisted in conditions of synaptic uncoupling. In contrast, pyramidal neurones were either unaffected by neurohypophysial peptides or showed one or several of the following effects: a decrease in firing rate in cells which were spontaneously active; a slight membrane hyperpolarization; and an increase in the rate of occurrence of spontaneous inhibitory postsynaptic potentials. We therefore propose that oxytocin and vasopressin excite directly a class of non-pyramidal inhibitory interneurones, whereas their observed effect on pyramidal neurones is indirect and inhibitory.
Keywords Action Potentials/drug effectsAnimalsArginine Vasopressin/ pharmacologyElectric Conductivity/drug effectsElectric StimulationHippocampus/drug effects/ physiologyMembrane Potentials/drug effectsNeurons/drug effects/ physiologyOxytocin/ pharmacologyPyramidal Tracts/drug effects/ physiologyRats
Identifiers
PMID: 6478205
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Structures
Citation
(ISO format)
MUHLETHALER, Michel, CHARPAK, S., DREIFUSS, Jean-Jacques. Contrasting effects of neurohypophysial peptides on pyramidal and non-pyramidal neurones in the rat hippocampus. In: Brain Research, 1984, vol. 308, n° 1, p. 97-107. https://archive-ouverte.unige.ch/unige:10097

182 hits

0 download

Update

Deposited on : 2010-08-06

Export document
Format :
Citation style :