UNIGE document Scientific Article
previous document  unige:100764  next document
add to browser collection
Title

The Elephant in the Room: The Role of Microtubules in Cancer

Authors
Published in Advances in Experimental Medicine and Biology. 2017, vol. 1002, p. 93-124
Abstract Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour constitutes the basis for many biological processes such as cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked to chromosomal instability, aneuploidy and development of drug resistances. The elephant in the room, however, is that despite all these evidences, the exact role of microtubules in malignancies remains elusive, partially due to the lack of clear genetic alterations linking microtubules to cancer. This review will discuss the molecular mechanisms that might alter microtubule dynamics in cancer cells, the pro and cons of the different theories linking these alterations to cancer progression, and the possible directions to address future key questions.
Keywords AneuploidyAnimalsCell TransformationNeoplastic/genetics/metabolism/pathologyChromosomal InstabilityGene Expression RegulationNeoplasticGenetic Predisposition to DiseaseHumansMicrotubules/genetics/metabolism/pathologyMitosisNeoplasms/genetics/metabolism/pathologyPhenotype
Identifiers
PMID: 28600784
Full text
Article (Published version) (781 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
CIRILLO, Luca, GOTTA, Monica, MERALDI, Patrick. The Elephant in the Room: The Role of Microtubules in Cancer. In: Advances in Experimental Medicine and Biology, 2017, vol. 1002, p. 93-124. https://archive-ouverte.unige.ch/unige:100764

32 hits

1 download

Update

Deposited on : 2017-12-21

Export document
Format :
Citation style :