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Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

Disanto, Giulio
Barro, Christian
Benkert, Pascal
Naegelin, Yvonne
Schädelin, Sabine
Giardiello, Antonella
Zecca, Chiara
Blennow, Kaj
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Published in Annals of Neurology. 2017, vol. 81, no. 6, p. 857-870
Abstract Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).
Keywords AdultAgedBiological AssayBiomarkers/bloodBrain/diagnostic imagingCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple Sclerosis/blood/cerebrospinal fluid/diagnostic imaging/physiopathologyNeurofilament Proteins/bloodPilot ProjectsRecurrenceSpinal Cord/diagnostic imaging
PMID: 28512753
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Article (Published version) (2.9 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Epilepsie et Chirurgie (149)
Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
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DISANTO, Giulio et al. Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis. In: Annals of Neurology, 2017, vol. 81, n° 6, p. 857-870. doi: 10.1002/ana.24954 https://archive-ouverte.unige.ch/unige:100708

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Deposited on : 2017-12-20

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