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Scientific article
English

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

Published inAnnals of Neurology, vol. 81, no. 6, p. 857-870
Publication date2017
Abstract

Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).

Keywords
  • Adult
  • Aged
  • Biological Assay
  • Biomarkers/blood
  • Brain/diagnostic imaging
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis/blood/cerebrospinal fluid/diagnostic imaging/physiopathology
  • Neurofilament Proteins/blood
  • Pilot Projects
  • Recurrence
  • Spinal Cord/diagnostic imaging
Citation (ISO format)
DISANTO, Giulio et al. Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis. In: Annals of Neurology, 2017, vol. 81, n° 6, p. 857–870. doi: 10.1002/ana.24954
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Article (Published version)
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Identifiers
ISSN of the journal0364-5134
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Technical informations

Creation20/11/2017 08:33:00
First validation20/11/2017 08:33:00
Update time15/03/2023 07:40:55
Status update15/03/2023 07:40:54
Last indexation17/01/2024 01:54:40
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