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Scientific article
English

Loss of muscle oxidative capacity after an extreme endurance run: the Paris-Dakar foot-race

Contributors

Höchli, D.; Schneiter, T.; Ferretti, Guido; Howald, H.; Claassen, H.; Moia, Christian; Atchou, G.; Belleri, M.; Veicsteinas, Arsenio; Hoppeler, H.

Published in

International journal of sports medicine, vol. 16, no. 6, p. 343-346

Publication date

1995

Abstract

We measured changes in maximal oxygen uptake capacity (VO2max), ventilation, heart rate, plasma lactate and speed at the end of an incremental exercise test as a consequence of a relay foot race from Paris to Dakar in 6 subjects. Additionally, anthropometric measurements were taken and muscle biopsies from M. vastus lateralis were obtained before and after the race. The latter were analyzed with morphometric methods for fiber size, capillarity and muscle ultrastructural composition. Weight specific VO2max was significantly reduced from 62.4 to 60.5 ml/min.kg after the race while absolute VO2max and the other endurance related functional variables remained unchanged. Body fat, thigh cross-sectional area and thigh volume showed tendential reduction immediately after the race but regained pre-race values within a few days. Fiber size and capillarity were not affected by the race. Volume density of total mitochondria was significantly reduced from 6.98 to 4.89% of fiber volume. Both subsarcolemmal and interfibrillar mitochondria were significantly reduced by 59 and 21%, respectively. The volume density of satellite cell was increased about three-fold whereas the content of lipofuscin remained constant. It is concluded that extreme endurance events such as a multi-stage relay race may induce a considerable loss of oxidative capacity of skeletal muscle tissue.

Keywords

  • Adipose Tissue/anatomy & histology
  • Adult
  • Anthropometry
  • Capillaries/ultrastructure
  • Exercise Test
  • Heart Rate
  • Humans
  • Lactates/blood
  • Lipofuscin/analysis
  • Male
  • Mitochondria, Muscle/ultrastructure
  • Muscle Fibers, Skeletal/ultrastructure
  • Muscle, Skeletal/anatomy & histology/blood supply/ metabolism/ultrastructure
  • Oxygen Consumption/ physiology
  • Paris
  • Physical Endurance
  • Respiration
  • Running/ physiology
  • Sarcolemma/ultrastructure
  • Senegal
  • Thigh/anatomy & histology

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

HÖCHLI, D. et al. Loss of muscle oxidative capacity after an extreme endurance run: the Paris-Dakar foot-race. In: International journal of sports medicine, 1995, vol. 16, n° 6, p. 343–346. doi: 10.1055/s-2007-973017

Identifiers

Journal ISSN

0172-4622
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Technical informations

Creation

06/08/2010 10:47:12

First validation

06/08/2010 10:47:12

Update

14/03/2023 15:57:23

Status update

14/03/2023 15:57:23

Last indexation

29/10/2024 16:23:55
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