Scientific Article - Case report
previous document  unige:100588  next document
add to browser collection

Pergolide as adjuvant therapy to amisulpride in the treatment of negative and depressive symptoms in schizophrenia

Roesch-Ely, D
Göhring, K
Gruschka, P
Pfüller, U
Burlon, M
Weisbrod, M
Published in Pharmacopsychiatry. 2006, vol. 39, no. 3, p. 115-116
Abstract Negative and cognitive symptoms of schizophrenia are associated with a hypodopaminergic state in the frontal cortex and do not respond to neuroleptics equally well as positive symptoms. Therefore pharmacological strategies, which increase dopamine metabolism in the mesocortical pathways, may prove beneficial to ameliorate these symptoms. We report on a case of a patient with paranoid schizophrenia, who still presented negative and depressive symptoms during treatment with amisulpride for more than 6 weeks. We prescribed pergolide (a mixed D1/D2 agonist) as adjuvant therapy to treat these symptoms. The patient showed an improvement of global psychopathology, decrease of negative and depressive symptoms, while no changes in positive symptoms nor EPS were present. For this patient, the adjuvant therapy of pergolide to amisulpride constituted a valid pharmacological approach to treat negative and depressive symptoms of schizophrenia, without increasing positive symptoms.
Keywords AdultAntipsychotic Agents/administration & dosageComorbidityDepressive Disorder/diagnosis/drug therapy/psychologyDopamine Agonists/administration & dosageDrug Therapy, CombinationFrontal Lobe/drug effectsHallucinations/diagnosis/drug therapy/psychologyHumansMaleNeural Pathways/drug effectsPergolide/administration & dosagePsychiatric Status Rating ScalesReceptors, Dopamine D1/agonistsReceptors, Dopamine D2/agonistsSchizophrenia, Paranoid/diagnosis/drug therapy/psychologySulpiride/administration & dosage/analogs & derivativesTreatment Outcome
PMID: 16721703
Full text
Article (Published version) (44 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
ROESCH-ELY, D et al. Pergolide as adjuvant therapy to amisulpride in the treatment of negative and depressive symptoms in schizophrenia. In: Pharmacopsychiatry, 2006, vol. 39, n° 3, p. 115-116. doi: 10.1055/s-2006-941488

201 hits

0 download


Deposited on : 2017-12-20

Export document
Format :
Citation style :