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Response inhibition or salience detection in the right ventrolateral prefrontal cortex?

Walther, Stephan
Friederich, Hans-Christoph
Stippich, Christoph
Weisbrod, Matthias
Published in Neuroreport. 2011, vol. 22, no. 15, p. 778-782
Abstract This study addresses the question of whether frontal activation in response-inhibition tasks is specifically associated with the suppression of a motor response. An alternative model suggests a role in the detection of behaviorally relevant or salient events. For this purpose, we used functional MRI with an auditory go/no-go paradigm. This paradigm allowed the disentangling of inhibition-related from salience-related effects, which were associated with different frontal regions. Importantly, the right ventrolateral prefrontal cortex consistently showed sensitivity for salience but not for inhibition requirements. This reflects a more general salience-detection mechanism, which is not specific for response-inhibition tasks.
Keywords AdultBehavior/physiologyFemaleHumansImage Interpretation, Computer-AssistedInhibition (Psychology)Magnetic Resonance ImagingMalePrefrontal Cortex/physiologyPsychomotor Performance/physiologyYoung Adult
PMID: 21876462
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WALTHER, Stephan et al. Response inhibition or salience detection in the right ventrolateral prefrontal cortex?. In: Neuroreport, 2011, vol. 22, n° 15, p. 778-782. doi: 10.1097/WNR.0b013e32834af670

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Deposited on : 2017-12-20

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