Article (Published version) (974 Kb) - Limited access to UNIGE
Response inhibition or salience detection in the right ventrolateral prefrontal cortex?
|Published in||Neuroreport. 2011, vol. 22, no. 15, p. 778-782|
|Abstract||This study addresses the question of whether frontal activation in response-inhibition tasks is specifically associated with the suppression of a motor response. An alternative model suggests a role in the detection of behaviorally relevant or salient events. For this purpose, we used functional MRI with an auditory go/no-go paradigm. This paradigm allowed the disentangling of inhibition-related from salience-related effects, which were associated with different frontal regions. Importantly, the right ventrolateral prefrontal cortex consistently showed sensitivity for salience but not for inhibition requirements. This reflects a more general salience-detection mechanism, which is not specific for response-inhibition tasks.|
|Keywords||Adult — Behavior/physiology — Female — Humans — Image Interpretation, Computer-Assisted — Inhibition (Psychology) — Magnetic Resonance Imaging — Male — Prefrontal Cortex/physiology — Psychomotor Performance/physiology — Young Adult|
|WALTHER, Stephan et al. Response inhibition or salience detection in the right ventrolateral prefrontal cortex?. In: Neuroreport, 2011, vol. 22, n° 15, p. 778-782. doi: 10.1097/WNR.0b013e32834af670 https://archive-ouverte.unige.ch/unige:100564|