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Scientific article
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Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study

ContributorsInternational Consortium on Lithium Genetics (ConLi+Gen)
Published inJAMA Psychiatry
Publication date2017
Abstract

Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ).

Citation (ISO format)
International Consortium on Lithium Genetics (ConLi+Gen). Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. In: JAMA Psychiatry, 2017. doi: 10.1001/jamapsychiatry.2017.3433
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accessLevelRestricted
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ISSN of the journal2168-622X
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Creation12/05/2017 3:28:00 PM
First validation12/05/2017 3:28:00 PM
Update time03/15/2023 7:38:52 AM
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