Effects of Antidiabetic Drugs on Gut Microbiota Composition

Montandon, Sophie; Jornayvaz, François

doi:10.3390/genes8100250

Scientific article

English

Effects of Antidiabetic Drugs on Gut Microbiota Composition

Contributors

Montandon, Sophie; Jornayvaz, François

Published in

Genes, vol. 8, no. 10

Publication date

2017

Abstract

Gut microbiota forms a catalog of about 1000 bacterial species; which mainly belong to the Firmicutes and Bacteroidetes phyla. Microbial genes are essential for key metabolic processes; such as the biosynthesis of short-chain fatty acids (SCFA); amino acids; bile acids or vitamins. It is becoming clear that gut microbiota is playing a prevalent role in pathologies such as metabolic syndrome; type 2 diabetes (T2D); inflammatory and bowel diseases. Obesity and related diseases; notably type 2 diabetes, induce gut dysbiosis. In this review; we aim to cover the current knowledge about the effects of antidiabetic drugs on gut microbiota diversity and composition as well as the potential beneficial effects mediated by specific taxa. Metformin is the first-line treatment against T2D. In addition to its glucose-lowering and insulin sensitizing effects, metformin promotes SCFA-producing and mucin-degrading bacteria. Other antidiabetic drugs discussed in this review show positive effects on dysbiosis; but without any consensus specifically regarding the Firmicutes to Bacteroidetes ratio. Thus, beneficial effects might be mediated by specific taxa.

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

MONTANDON, Sophie, JORNAYVAZ, François. Effects of Antidiabetic Drugs on Gut Microbiota Composition. In: Genes, 2017, vol. 8, n° 10. doi: 10.3390/genes8100250

Article (Published version)

Identifiers

PID : unige:100540
DOI : 10.3390/genes8100250
PMID : 28973971

Journal ISSN

1462-6438

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15/12/2017 11:25:00

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15/12/2017 11:25:00

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30/03/2023 10:51:13

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30/03/2023 10:51:13

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31/10/2024 09:08:27

Effects of Antidiabetic Drugs on Gut Microbiota Composition

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation