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Title

Morphological and electrophysiological evidence for postsynaptic localization of functional oxytocin receptors in the rat dorsal motor nucleus of the vagus nerve
Authors
Dubois-Dauphin, Michel
Raggenbass, Mario
Widmer, H.
Tribollet, Eliane
Dreifuss, Jean-Jacques
Published in Brain Research. 1992, vol. 575, no. 1, p. 124-131
Abstract The vagal complex is innervated by oxytocin immunoreactive axons of hypothalamic origin. The presence of oxytocin binding sites in the dorsal motor nucleus of the vagus nerve of the rat was evidenced by autoradiography with a radioiodinated oxytocin antagonist as ligand. Two weeks following a unilateral vagotomy, distal to the nodose ganglion, binding sites were reduced below the level of detection in the ipsilateral dorsal motor nucleus of the vagus nerve. Choline acetyltransferase immunoreactivity was also markedly reduced in the vagal motoneurons whose axons had been transected. Electrophysiological studies were performed in vitro in brainstem slices from control rats. In antidromically identified vagal motoneurones, oxytocin applied at 0.1-1.0 microM either caused a reversible depolarization or generated, under voltage-clamp conditions, a transient inward current. These responses persisted under the condition of synaptic uncoupling. Taken together these observations favour the notion that oxytocin of hypothalamic origin acts directly on rat vagal motoneurones.
Keywords Animals — Autoradiography — Axons/chemistry/physiology — Brain Stem/ chemistry — Choline O-Acetyltransferase/analysis — Immunoenzyme Techniques — Male — Membrane Potentials/physiology — Motor Neurons/ chemistry/physiology — Oxytocin — Rats — Rats, Inbred Strains — Receptors, Angiotensin/ analysis — Receptors, Oxytocin — Synapses/ chemistry — Vagus Nerve/ chemistry/physiology/ultrastructure
Identifiers
PMID: 1324083
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Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation
(ISO format) 		DUBOIS-DAUPHIN, Michel et al. Morphological and electrophysiological evidence for postsynaptic localization of functional oxytocin receptors in the rat dorsal motor nucleus of the vagus nerve. In: Brain Research, 1992, vol. 575, n° 1, p. 124-131. https://archive-ouverte.unige.ch/unige:10048

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Deposited on : 2010-08-06

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