en
Scientific article
English

Temporal variability and spatial diffusion of the N2 event-related potential in high-functioning patients with schizophrenia

Published inSchizophrenia Research, vol. 131, no. 1-3, p. 206-213
Publication date2011
Abstract

Recent theories of schizophrenia have proposed a fundamental instability of information processing on a neurophysiological level, which can be measured as an increase in latency variability of event-related potentials (ERPs). If this reflects a fundamental deficit of the schizophrenic illness, it should also occur in high-functioning patients. These patients have also been observed to show a more diffuse activation pattern in neuroimaging studies, which is thought to reflect compensatory processes to maintain task performance. In the present study we investigated temporal variability and spatial diffusion of the visual N2 component in a group of high-functioning patients with preserved cognitive performance. 28 patients with schizophrenia and 28 control participants matched for gender, age and education participated in the study. Subjects performed a visual Go/Nogo task, while event-related potentials were obtained. Trial-to-trial latency variability was calculated with a Wavelet-based method. Patients with schizophrenia showed a robust increase in N2 latency variability at electrodes Fz and Cz in all task conditions. Regarding spatial distribution healthy participants showed a focused fronto-central N2 peak. In contrast, patients with schizophrenia showed a more diffuse pattern and additional negative peaks over lateral electrodes in the Nogo condition. These results clearly show that even in high-functioning patients with schizophrenia a higher temporal variability of ERPs can be observed. This provides support for temporal instability of information processing as a fundamental deficit associated with schizophrenia. The more diffuse scalp distribution might reflect processes that compensate for this instability when cognitive control is required.

Keywords
  • Adolescent
  • Adult
  • Analysis of Variance
  • Brain Mapping
  • Case-Control Studies
  • Choice Behavior/physiology
  • Electroencephalography
  • Evoked Potentials/physiology
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Photic Stimulation/methods
  • Reaction Time/physiology
  • Schizophrenia/physiopathology
  • Statistics as Topic
  • Young Adult
Affiliation Not a UNIGE publication
Citation (ISO format)
RENTROP, Mirjam et al. Temporal variability and spatial diffusion of the N2 event-related potential in high-functioning patients with schizophrenia. In: Schizophrenia Research, 2011, vol. 131, n° 1-3, p. 206–213. doi: 10.1016/j.schres.2011.06.020
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0920-9964
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