en
Scientific article
English

MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers

Published inPPAR Research, vol. 2017, 7058424
Publication date2017
Abstract

Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-dependent nuclear receptors, which control the transcription of genes involved in energy homeostasis and inflammation and cell proliferation/differentiation. Alterations of PPARs' expression and/or activity are commonly associated with metabolic disorders occurring with obesity, type 2 diabetes, and fatty liver disease, as well as with inflammation and cancer. Emerging evidence now indicates that microRNAs (miRNAs), a family of small noncoding RNAs, which fine-tune gene expression, play a significant role in the pathophysiological mechanisms regulating the expression and activity of PPARs. Herein, the regulation of PPARs by miRNAs is reviewed in the context of metabolic disorders, inflammation, and cancer. The reciprocal control of miRNAs expression by PPARs, as well as the therapeutic potential of modulating PPAR expression/activity by pharmacological compounds targeting miRNA, is also discussed.

Citation (ISO format)
PORTIUS, Dorothea, SOBOLEWSKI, Cyril, FOTI, Michelangelo. MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. In: PPAR Research, 2017, vol. 2017, p. 7058424. doi: 10.1155/2017/7058424
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1687-4757
443views
3downloads

Technical informations

Creation11/07/2017 11:41:00 AM
First validation11/07/2017 11:41:00 AM
Update time03/15/2023 7:37:44 AM
Status update03/15/2023 7:37:44 AM
Last indexation05/02/2024 7:49:56 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack