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Scientific Article
unige:100432 
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MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers |
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| Authors | ||
| Published in | PPAR Research. 2017, vol. 2017, p. 7058424 | |
| Abstract | Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-dependent nuclear receptors, which control the transcription of genes involved in energy homeostasis and inflammation and cell proliferation/differentiation. Alterations of PPARs' expression and/or activity are commonly associated with metabolic disorders occurring with obesity, type 2 diabetes, and fatty liver disease, as well as with inflammation and cancer. Emerging evidence now indicates that microRNAs (miRNAs), a family of small noncoding RNAs, which fine-tune gene expression, play a significant role in the pathophysiological mechanisms regulating the expression and activity of PPARs. Herein, the regulation of PPARs by miRNAs is reviewed in the context of metabolic disorders, inflammation, and cancer. The reciprocal control of miRNAs expression by PPARs, as well as the therapeutic potential of modulating PPAR expression/activity by pharmacological compounds targeting miRNA, is also discussed. | |
| Identifiers | DOI: 10.1155/2017/7058424 PMID: 28167956 | |
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| Research group | Obésité et syndrome métabolique (803) | |
| Citation (ISO format) | PORTIUS, Dorothea, SOBOLEWSKI, Cyril, FOTI, Michelangelo. MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. In: PPAR Research, 2017, vol. 2017, p. 7058424. https://archive-ouverte.unige.ch/unige:100432 |
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