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Titles listVasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem
Titles listVasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem
Scientific Article
unige:10039 
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Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem |
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| Authors | ||
| Published in | Brain Research. 1989, vol. 483, no. 1, p. 164-169 | |
| Abstract | The effect of arginine vasopressin (AVP) on neurones in the dorsal cochlear nucleus (DCN) of young guinea-pigs of either sex was investigated in brainstem slices. Most impaled neurones fired in a regular manner, either spontaneously or following a depolarizing current injection. AVP, at concentrations of 10-1000 nM, excited 19/19 neurones from male and 16/19 neurones from female animals. This effect of AVP was concentration-dependent and could be mimicked by the V1 agonist [Phe2,Orn8]VT. Oxytocin was less potent than AVP and a selective V2 agonist, deamino-DAVP, was without effect. Thus, a class of DCN neurones is probably endowed with functional V1 vasopressin receptors. By making use of an antibody raised against the vasopressin-related glycopeptide, dense AVP-like immunoreactivity was found in the DCN of young animals of either sex. | |
| Keywords | Action Potentials/drug effects — Animals — Arginine Vasopressin/ pharmacology — Brain Stem/drug effects/metabolism/ physiology — Cochlear Nerve/drug effects/metabolism/ physiology — Female — Guinea Pigs — Male — Oxytocin/pharmacology | |
| Identifiers | PMID: 2706504 | |
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| Citation (ISO format) | CHARPAK, S. et al. Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem. In: Brain Research, 1989, vol. 483, n° 1, p. 164-169. https://archive-ouverte.unige.ch/unige:10039 |
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