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Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem

Charpak, S.
Dreifuss, Jean-Jacques
Published in Brain Research. 1989, vol. 483, no. 1, p. 164-169
Abstract The effect of arginine vasopressin (AVP) on neurones in the dorsal cochlear nucleus (DCN) of young guinea-pigs of either sex was investigated in brainstem slices. Most impaled neurones fired in a regular manner, either spontaneously or following a depolarizing current injection. AVP, at concentrations of 10-1000 nM, excited 19/19 neurones from male and 16/19 neurones from female animals. This effect of AVP was concentration-dependent and could be mimicked by the V1 agonist [Phe2,Orn8]VT. Oxytocin was less potent than AVP and a selective V2 agonist, deamino-DAVP, was without effect. Thus, a class of DCN neurones is probably endowed with functional V1 vasopressin receptors. By making use of an antibody raised against the vasopressin-related glycopeptide, dense AVP-like immunoreactivity was found in the DCN of young animals of either sex.
Keywords Action Potentials/drug effectsAnimalsArginine Vasopressin/ pharmacologyBrain Stem/drug effects/metabolism/ physiologyCochlear Nerve/drug effects/metabolism/ physiologyFemaleGuinea PigsMaleOxytocin/pharmacology
Stable URL http://archive-ouverte.unige.ch/unige:10039
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PMID: 2706504

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Deposited on : 2010-08-06

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