en
Scientific article
English

Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem

Published inBrain research, vol. 483, no. 1, p. 164-169
Publication date1989
Abstract

The effect of arginine vasopressin (AVP) on neurones in the dorsal cochlear nucleus (DCN) of young guinea-pigs of either sex was investigated in brainstem slices. Most impaled neurones fired in a regular manner, either spontaneously or following a depolarizing current injection. AVP, at concentrations of 10-1000 nM, excited 19/19 neurones from male and 16/19 neurones from female animals. This effect of AVP was concentration-dependent and could be mimicked by the V1 agonist [Phe2,Orn8]VT. Oxytocin was less potent than AVP and a selective V2 agonist, deamino-DAVP, was without effect. Thus, a class of DCN neurones is probably endowed with functional V1 vasopressin receptors. By making use of an antibody raised against the vasopressin-related glycopeptide, dense AVP-like immunoreactivity was found in the DCN of young animals of either sex.

Keywords
  • Action Potentials/drug effects
  • Animals
  • Arginine Vasopressin/ pharmacology
  • Brain Stem/drug effects/metabolism/ physiology
  • Cochlear Nerve/drug effects/metabolism/ physiology
  • Female
  • Guinea Pigs
  • Male
  • Oxytocin/pharmacology
Citation (ISO format)
CHARPAK, S. et al. Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem. In: Brain research, 1989, vol. 483, n° 1, p. 164–169. doi: 10.1016/0006-8993(89)90049-8
Identifiers
ISSN of the journal0006-8993
460views
0downloads

Technical informations

Creation08/06/2010 10:47:04 AM
First validation08/06/2010 10:47:04 AM
Update time03/14/2023 3:57:17 PM
Status update03/14/2023 3:57:17 PM
Last indexation01/15/2024 9:04:17 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack