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Title

Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem
Authors
Charpak, S.
Dubois-Dauphin, Michel
Raggenbass, Mario
Dreifuss, Jean-Jacques
Published in Brain Research. 1989, vol. 483, no. 1, p. 164-169
Abstract The effect of arginine vasopressin (AVP) on neurones in the dorsal cochlear nucleus (DCN) of young guinea-pigs of either sex was investigated in brainstem slices. Most impaled neurones fired in a regular manner, either spontaneously or following a depolarizing current injection. AVP, at concentrations of 10-1000 nM, excited 19/19 neurones from male and 16/19 neurones from female animals. This effect of AVP was concentration-dependent and could be mimicked by the V1 agonist [Phe2,Orn8]VT. Oxytocin was less potent than AVP and a selective V2 agonist, deamino-DAVP, was without effect. Thus, a class of DCN neurones is probably endowed with functional V1 vasopressin receptors. By making use of an antibody raised against the vasopressin-related glycopeptide, dense AVP-like immunoreactivity was found in the DCN of young animals of either sex.
Keywords Action Potentials/drug effects — Animals — Arginine Vasopressin/ pharmacology — Brain Stem/drug effects/metabolism/ physiology — Cochlear Nerve/drug effects/metabolism/ physiology — Female — Guinea Pigs — Male — Oxytocin/pharmacology
Identifiers
PMID: 2706504
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Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation
(ISO format) 		CHARPAK, S. et al. Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem. In: Brain Research, 1989, vol. 483, n° 1, p. 164-169. doi: 10.1016/0006-8993(89)90049-8 https://archive-ouverte.unige.ch/unige:10039

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Deposited on : 2010-08-06

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