UNIGE document Scientific Article
previous document  unige:10037  next document
add to browser collection

Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve

Charpak, S.
Armstrong, W. E.
Dreifuss, Jean-Jacques
Published in Brain research. 1984, vol. 300, no. 1, p. 83-89
Abstract Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.
Keywords AnimalsArginine Vasopressin/analogs & derivatives/pharmacologyMaleMedulla Oblongata/analysis/ drug effectsOrgan SpecificityOxytocin/analogs & derivatives/ pharmacologyRatsRats, Inbred StrainsReceptors, Cell Surface/analysisReceptors, OxytocinStimulation, ChemicalVagus Nerve/analysis/ drug effects
PMID: 6329430
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
(ISO format)
CHARPAK, S. et al. Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve. In: Brain research, 1984, vol. 300, n° 1, p. 83-89. https://archive-ouverte.unige.ch/unige:10037

489 hits

0 download


Deposited on : 2010-08-06

Export document
Format :
Citation style :