UNIGE document Scientific Article
previous document  unige:100330  next document
add to browser collection

Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells

Published in Frontiers in Immunology. 2016, vol. 7, no. 7, 684
Abstract Lymph node stromal cells (LNSCs) have newly been promoted to the rank of new modulators of T cell responses. The different non-hematopoietic cell subsets in lymph node (LN) were considered for years as a simple scaffold, forming routes and proper environment for antigen (Ag)-lymphocyte encountering. Deeper characterization of those cells has recently clearly shown their impact on both dendritic cell and T cell functions. In particular, lymphatic endothelial cells (LECs) control lymphocyte trafficking and homeostasis in LNs and limit adaptive immune responses. Therefore, the new role of LECs in shaping immune responses has drawn the attention of immunologists. Striking is the discovery that LECs, among other LNSCs, ectopically express a large range of peripheral tissue-restricted Ags (PTAs), and further present PTA-derived peptides through major histocompatibility class I molecules to induce self-reactive CD8(+) T cell deletional tolerance. In addition, both steady-state and tumor-associated LECs were described to be capable of exogenous Ag cross-presentation. Whether LECs can similarly impact CD4(+) T cell responses through major histocompatibility class II restricted Ag presentation is still a matter of debate. Here, we review and discuss our current knowledge on the contribution of Ag-presenting LECs as regulators of peripheral T cell responses in different immunological contexts, including autoimmunity and cancer.
Keywords Aging/metabolism/pathologyAnimalsApolipoproteins E/genetics/metabolismAtherosclerosis/metabolism/pathologyCell Movement/physiologyCholesterolLDL/bloodCollagen/metabolismConnexins/genetics/metabolismDendritic Cells/metabolism/pathologyDietHigh-FatDisease ModelsAnimalEndothelial Cells/metabolism/pathologyFatty Acids/metabolismLymphatic Vessels/metabolism/pathologyMacrophages/metabolism/pathologyMiceInbred C57BLKnockoutT-Lymphocytes/metabolism/pathologyTriglycerides/blood
PMID: 28127298
Full text
Article (Published version) (1.4 MB) - public document Free access
Research group Pathologie et immunologie (906)
(ISO format)
HUMBERT, Marion, HUGUES, Stéphanie, DUBROT ARMENDARIZ, Juan. Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells. In: Frontiers in Immunology, 2016, vol. 7, n° 7, p. 684. doi: 10.3389/fimmu.2016.00684 https://archive-ouverte.unige.ch/unige:100330

315 hits



Deposited on : 2017-12-14

Export document
Format :
Citation style :