Scientific article
Open access

Response profiles of murine spiral ganglion neurons on multi-electrode arrays

Published inJournal of Neural Engineering, vol. 13, no. 1, 016011
Publication date2016

Cochlear implants (CIs) have become the gold standard treatment for deafness. These neuroprosthetic devices feature a linear electrode array, surgically inserted into the cochlea, and function by directly stimulating the auditory neurons located within the spiral ganglion, bypassing lost or not-functioning hair cells. Despite their success, some limitations still remain, including poor frequency resolution and high-energy consumption. In both cases, the anatomical gap between the electrode array and the spiral ganglion neurons (SGNs) is believed to be an important limiting factor. The final goal of the study is to characterize response profiles of SGNs growing in intimate contact with an electrode array, in view of designing novel CI devices and stimulation protocols, featuring a gapless interface with auditory neurons.

  • Action Potentials/physiology
  • Animals
  • Cochlear Implants
  • Electric Stimulation Therapy/instrumentation
  • Equipment Design
  • Equipment Failure Analysis
  • Mice
  • Mice
  • Inbred C57BL
  • Microarray Analysis/instrumentation
  • Microelectrodes
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spiral Ganglion/cytology/physiology
Citation (ISO format)
HAHNEWALD, Stefan et al. Response profiles of murine spiral ganglion neurons on multi-electrode arrays. In: Journal of Neural Engineering, 2016, vol. 13, n° 1, p. 016011. doi: 10.1088/1741-2560/13/1/016011
Main files (1)
Article (Published version)
ISSN of the journal1741-2560

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