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Response profiles of murine spiral ganglion neurons on multi-electrode arrays

Hahnewald, Stefan
Tscherter, Anne
Marconi, Emanuele
Streit, Jürg
Widmer, Hans Rudolf
Garnham, Carolyn
Benav, Heval
Mueller, Marcus
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Published in Journal of Neural Engineering. 2016, vol. 13, no. 1, 016011
Abstract Cochlear implants (CIs) have become the gold standard treatment for deafness. These neuroprosthetic devices feature a linear electrode array, surgically inserted into the cochlea, and function by directly stimulating the auditory neurons located within the spiral ganglion, bypassing lost or not-functioning hair cells. Despite their success, some limitations still remain, including poor frequency resolution and high-energy consumption. In both cases, the anatomical gap between the electrode array and the spiral ganglion neurons (SGNs) is believed to be an important limiting factor. The final goal of the study is to characterize response profiles of SGNs growing in intimate contact with an electrode array, in view of designing novel CI devices and stimulation protocols, featuring a gapless interface with auditory neurons.
Keywords Action Potentials/physiologyAnimalsCochlear ImplantsElectric Stimulation Therapy/instrumentationEquipment DesignEquipment Failure AnalysisMiceMiceInbred C57BLMicroarray Analysis/instrumentationMicroelectrodesReproducibility of ResultsSensitivity and SpecificitySpiral Ganglion/cytology/physiology
PMID: 26656212
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Research group Groupe Pascal Senn (954)
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HAHNEWALD, Stefan et al. Response profiles of murine spiral ganglion neurons on multi-electrode arrays. In: Journal of Neural Engineering, 2016, vol. 13, n° 1, p. 016011. doi: 10.1088/1741-2560/13/1/016011 https://archive-ouverte.unige.ch/unige:100300

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Deposited on : 2017-12-14

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