Urogenital and breast imaging plays a significant role in patient care in oncological and patients with other pathologic conditions. Despite the fact that the spectrum of pathologies is huge, in most domains, evolution of imaging allowed a transition from pure morphological studies towards more sophisticated techniques that allow tissue characterisation and incorporate functional information. In the following pages some of these evolutions will be described. The role of new CT techniques will be particularly discussed. Dual-energy CT (DECT) and its application in oncological and non-oncological urinary tract pathologies as well as in adrenal lesions characterisation will be presented. New CT techniques for exploration of urogenital fistulas, using functional information will be detailed. In another chapter, the evolution towards functional breast imaging will be discussed, with special mention of the role of multiparametric MR (MP-MR) and PET/MR in staging of breasts cancer patients.