The gut-bone axis : microbial metabolism and nutritional interventions for bone health

Article Article scientifique Revue de la littérature The gut-bone axis : microbial metabolism and nutritional interventions for bone health eng 2026-05-22 2026-12-31 author Rodriguez Bryant Alba 0000-0002-9835-2762 Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park, Lausanne, Switzerland.,Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 989927 author Papageorgiou Maria Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 926139 Département de médecine (DEMED) author Horcajada Marie-Noëlle Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park, Lausanne, Switzerland. author Biver Emmanuel Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 714511 Département de médecine (DEMED) author Ferrari Serge Livio 0000-0002-1372-4417 Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 24314 Département de médecine (DEMED) author Bonnet Nicolas Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park, Lausanne, Switzerland. 649969 Département de médecine (DEMED) 2675093 10.1080/19490976.2026.2675093 42171633 1949-0976 PMC13203023 Osteoporosis is a prevalent condition characterized by a rapid decline in bone mineral density and distorted microarchitecture, which leads to increased bone fragility. The gut microbiota and its metabolites play a crucial role in the development and progression of osteoporosis by influencing gut permeability, nutrient digestion and absorption, pH balance, and immune regulation. Nutritional interventions aimed at modulating gut microbiota, through postbiotics (butyrate), probiotics (<i>Bifidobacterium animalis</i> or <i>Lacticaseibacillus rhamnosus LGG</i> ), prebiotics (fructo-oligosaccharides), synbiotics, and specific dietary patterns (e.g. Mediterranean and vegetarian diets) have emerged as promising strategies to mitigate bone loss associated with aging. This review investigates the communication between the gut and bone, summarizing the underlying mechanisms and providing an updated review on microbial metabolites. Additionally, it examines recent research on probiotics and their metabolic contributions, highlighting potential gaps in the current understanding of this field. Bone Fermented Metabolites Nutrition Osteoporosis Prebiotics Probiotics Synbiotics Humans Probiotics / administration & dosage Bone and Bones / metabolism Prebiotics / administration & dosage Osteoporosis / metabolism Osteoporosis / microbiology Osteoporosis / diet therapy Osteoporosis / prevention & control Gastrointestinal Microbiome / physiology Animals Gastrointestinal Tract / microbiology Gastrointestinal Tract / metabolism Bacteria / metabolism Bacteria / classification Synbiotics / administration & dosage Dewey 616 56 Département de médecine 221 false 289 Métabolisme osseux 544 Gut microbes 18 1 e8a52349-399a-4c90-b9f6-0595c7c7a1c8 Article (Published version) Public KGMI_18_2675093.pdf 2554814 application/pdf CC BY-NC-4.0 69394d48092b394f20f1325554966b081985f94527ffcdd15d0cbdfea37e9b80 openAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Rodriguez Bryant, Alba