Investigating the molecular mechanism of aversive social experience plasticity

Diplôme Master Investigating the molecular mechanism of aversive social experience plasticity eng 2024-09-12 author Mohrhauer Lucy Katharina 986186 director Bellone Camilla 0000-0002-6774-6275 559161 Département de neurosciences fondamentales (NEUFO) director Espinosa Ahumada Pedro Alejandro 0000-0002-2202-8982 883451 Département de neurosciences fondamentales (NEUFO) 68 This study embarks on a scientific exploration into the intricate world of mouse social behaviour, with a focus on aversive social experience plasticity. First impressions are formed rapidly based on survival instincts, helping us assess whether an interaction is safe or threatening. This evaluation, known as social valence, determines whether we perceive an interaction as positive or negative. Positive social valence encourages further social engagement, while negative valence may lead to avoidance. However, the way the brain encodes for negative social valence remains unclear. Delving into the neural circuitry of social behaviour, our research builds upon previous discoveries implicating the D1+ neurons of the anterior insular cortex (AIC) to D1+ neurons of the lateral nucleus accumbens (lNAc) pathway. As previous results have shown that metabotropic glutamate receptors 1 (mGluR1) and 5 (mGluR5) in the nucleus accumbens shell modulate Long-term depression (LTD) in the context of social motivation and learning (Turner et al., 2018). In this context, we investigate the role of mGluR1 and mGluR5 receptors in the lNAc with regard to aversive social plasticity. Our experiments offer some insights into the neurobiological mechanisms underlying social behaviour and learning. Social interaction Social valence MGluR Synaptic plasticity Aversive social interactions Lateral NAc D1+ neurons Dewey 616.8 Maîtrise universitaire interdisciplinaire en neurosciences 53 Département de neurosciences fondamentales 21A false 973 Les dysfonctions synaptiques du cerveau 971 15cd2834-c76d-4726-be44-04e0bca0d9ea Master thesis Restricted LucyMohrhauer_Master_Thesis_2024.pdf 15635996 application/pdf 9bcdf376c24eda4c28fbffeb196ca81e83f530a4484ec1dbd64a198261ef5377 restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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