Cerebro-spinal somatotopic organization uncovered through functional connectivity mapping

Article Article scientifique Article Cerebro-spinal somatotopic organization uncovered through functional connectivity mapping eng 2024-08-20 2024-09-05 author Landelle Caroline 767517 author Kinany Nawal 873306 author De Leener Benjamin author Murphy Nicholas D. author Lungu Ovidiu author Marchand-Pauvert Véronique author Van De Ville Dimitri 0000-0002-2879-3861 638484 Département de radiologie et informatique médicale (RADIO) author Doyon Julien 98518 1-14 10.1162/imag_a_00284 2837-6056 https://direct.mit.edu/imag/article/doi/10.1162/imag_a_00284/124091/Cerebro-spinal-somatotopic-organization-uncovered <p>Somatotopy, the topographical arrangement of sensorimotor pathways corresponding to distinct body parts, is a fundamental feature of the human central nervous system (CNS). Traditionally, investigations into brain and spinal cord somatotopy have been conducted independently, primarily utilizing body stimulations or movements. To date, however, no study has probed the somatotopic arrangement of cerebro-spinal functional connections in vivo in humans. In this study, we used simultaneous brain and cervical spinal cord functional magnetic resonance imaging (fMRI) to demonstrate how the coordinated activities of these two CNS levels at rest can reveal their shared somatotopy. Using functional connectivity analyses, we mapped preferential correlation patterns between each spinal cord segment and distinct brain regions, revealing a somatotopic gradient within the cortical sensorimotor network. We then validated this large-scale somatotopic organization through a complementary data-driven analysis, where we effectively identified spinal cord segments through the connectivity profiles of their voxels with the sensorimotor cortex. These findings underscore the potential of resting-state cerebro-spinal cord fMRI to probe the large-scale organization of the human sensorimotor system with minimal experimental burden, holding promise for gaining a more comprehensive understanding of normal and impaired somatosensory-motor functions.</p> Cerebro-spinal fMRI Resting-state Somatotopy Functional connectivity Dewey 616.0757 Swiss National Science Foundation Imaging and Modeling of Simultaneous Brain and Cervical Spinal Cord 207493 CH Projects 62 Département de radiologie et informatique médicale 227 false 552 Traitement d'images médicales 893 https://doi.org/10.1162/imag_a_00284 https://openneuro.org/datasets/ds005075/ https://github.com/CarolineLndl/BrainSpineSomatotopy2024 Imaging neuroscience 2 a26da61f-b012-4d7c-b0f7-01951896a9e6 Article (Published version) Public imag_a_00284.pdf 3148923 application/pdf CC BY-4.0 1ceb4c4f5f3c62be75b111d3250ef50e8c8a794f6100380a5f7e71aea409d3df openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Cerebro-spinal somatotopic organization uncovered through functional connectivity mapping	Imaging neuroscience			2024	58	61

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Doyon, Julien