Endoscopic Variceal Therapy With Multisystemic Glue Embolism : A Case Report and Narrative Review of a Rare but Severe Complication

Article Article scientifique Rapport de cas Endoscopic Variceal Therapy With Multisystemic Glue Embolism : A Case Report and Narrative Review of a Rare but Severe Complication eng 2025-11-10 2025 author Penati Monica 0009-0003-8541-1043 Intensive Care Service, Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland, hug-ge.ch. author Lazzaroni Silvia Intensive Care Service, Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland, hug-ge.ch. author Neury Marine Department of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland, hug-ge.ch. 982428 author Bendjelid Karim 0000-0002-7921-7207 Intensive Care Service, Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland, hug-ge.ch. 527948 Département d'anesthésiologie, pharmacologie et soins intensifs (APSIC) 4510213 10.1155/crcc/4510213 41221375 2090-6420 PMC12598399 https://onlinelibrary.wiley.com/doi/10.1155/crcc/4510213 Gastroesophageal variceal bleeding is a life-threatening complication of portal hypertension in patients with cirrhosis. Endoscopic cyanoacrylate injection is an established therapy for variceal hemorrhage, but it may lead to rare systemic complications, including glue embolization. The authors report the case of a patient with decompensated cirrhosis who developed acute gastroesophageal variceal bleeding, managed with endoscopic variceal ligation and cyanoacrylate injection. Postprocedural investigations revealed multiple emboli involving the cerebral, pulmonary, coronary, and renal vascular territories. The present case report and review of the literature highlight the need for increased awareness of glue embolization as a potential adverse effect of cyanoacrylate therapy. Careful patient selection, refined endoscopic technique, and close postprocedure monitoring are essential to minimizing the risks of embolization, reducing complications and optimizing outcomes. Cyanoacrylate glue embolization Decompensated cirrhosis Gastroesophageal variceal bleeding Dewey 616.07 Dewey 617 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 137 Département de pathologie et immunologie 21F false 570 Groupe de recherche en hémodynamique 913 Case reports in critical care 2025 c444eef0-89f4-4b24-8e2e-3e78add2cd1c Article (Published version) Public Article_scientifique_from_europePmc.pdf 2748624 application/pdf CC BY-4.0 b4e272ec6ba5a7e8a2ba96087deb8d69fb82077ba73b166404d46cbde755173e openAccess Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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Endoscopic Variceal Therapy With Multisystemic Glue Embolism : A Case Report and Narrative Review of a Rare but Severe Complication	Case reports in critical care			2025	12	33

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