Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice

Article Article scientifique Article Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice eng 2022-09-07 2023-02 author Pascoli Vincent Jean 703155 author Hiver Agnès 798350 author Li Yue 892648 author Harada Masaya 825934 author Esmaeili Vahid 979415 author Luscher Christian 0000-0001-7917-4596 34378 448-458 10.1038/s41386-022-01429-8 36071131 0893-133X PMC9852591 Addiction-related compulsion-like behavior can be modeled in rodents with drug self-administration (SA) despite harmful consequences. Recent studies suggest that the potentiation of glutamatergic transmission at the orbitofrontal cortex (OFC) to dorsal striatum (DS) synapses drives the transition from controlled to compulsion-like SA. However, the timing of the induction of this synaptic plasticity remains elusive. Here, mice were first allowed to intravenously self-administer cocaine. When mice had to endure a risk of electrical foot shock, only a fraction persevered in cocaine SA. In these persevering mice, we recorded high A/N ratios (AMPA-R/NMDA-R: α-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid receptor/N-methyl-D-aspartate receptor) in both types of spiny projection neurons (i.e., D1 and D2 dopamine receptor-expressing SPNs). By contrast, when we prepared slices at the end of the acquisition period, in all mice, the A/N was high in D1R- but not D2R-SPNs. These results indicate that the transition to compulsion-like cocaine SA emerges during the punishment sessions, where synapses onto D2R-SPNs are strengthened. In renouncing individuals, the cocaine-evoked strengthening in D1R-SPNs is lost. Our study thus reveals the cell-type specific sequence of the induction of plasticity that eventually may cause compulsion-like SA. Mice Animals Cocaine Punishment Nucleus Accumbens / metabolism Neuronal Plasticity / physiology Behavior, Addictive Receptors, Dopamine D1 / metabolism Dewey 616.8 53 Département de neurosciences fondamentales 21A 61 Département des neurosciences cliniques 226 false 271 Mécanismes cellulaires de la dépendance et de l'addiction 520 Neuropsychopharmacology 48 3 e878f09b-f2ed-40f0-a763-0666013aa409 Article (Published version) Public Article-scientifique-from-europePmc.pdf 3328278 application/pdf CC BY-4.0 c4930e96-5153-4298-ab72-a8f51081a675 Appendix Public 41386_2022_1429_MOESM1_ESM.pdf 5094167 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice	Neuropsychopharmacology			2023	176	187

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Esmaeili, Vahid