Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses

Article Article scientifique Article Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses eng 2023-07 author Zwygart Arnaud Charles-Antoine 0000-0002-0713-1105 849319 Département de microbiologie et médecine moléculaire (MIMOL) author Medaglia Chiara 912920 author Huber Robin 0000-0001-9164-6584 751322 Section des sciences pharmaceutiques (FARMA) author Poli Romain 0000-0001-7474-1854 974142 Département de microbiologie et médecine moléculaire (MIMOL) author Marcourt Laurence 0000-0002-9614-1099 729234 Section des sciences pharmaceutiques (FARMA) author Schnee Sylvain author Michellod Emilie author Mazel-Sanchez Beryl 0000-0001-5446-3017 827346 author Constant Samuel author Huang Song author Bekliz Meriem 952376 Département de médecine (DEMED) author Clément Leboube Sophie 120543 Département de microbiologie et médecine moléculaire (MIMOL) Sophie Clément author Gindro Katia author Ferreira Queiroz Emerson 135675 Section des sciences pharmaceutiques (FARMA) author Tapparel Caroline 0000-0002-0411-6567 27039 Département de microbiologie et médecine moléculaire (MIMOL) 114825 10.1016/j.biopha.2023.114825 37148860 0753-3322 PMC10158552 https://www.sciencedirect.com/science/article/pii/S0753332223006157 <p>Over the last century, the number of epidemics caused by RNA viruses has increased and the current SARS-CoV-2 pandemic has taught us about the compelling need for ready-to-use broad-spectrum antivirals. In this scenario, natural products stand out as a major historical source of drugs. We analyzed the antiviral effect of 4 stilbene dimers [1 (trans-δ-viniferin); 2 (11',13'-di-O-methyl-trans-δ-viniferin), 3 (11,13-di-O-methyl-trans-δ-viniferin); and 4 (11,13,11',13'-tetra-O-methyl-trans-δ-viniferin)] obtained from plant substrates using chemoenzymatic synthesis against a panel of enveloped viruses. We report that compounds 2 and 3 display a broad-spectrum antiviral activity, being able to effectively inhibit several strains of Influenza Viruses (IV), SARS-CoV-2 Delta and, to some extent, Herpes Simplex Virus 2 (HSV-2). Interestingly, the mechanism of action differs for each virus. We observed both a direct virucidal and a cell-mediated effect against IV, with a high barrier to antiviral resistance; a restricted cell-mediated mechanism of action against SARS-CoV-2 Delta and a direct virustatic activity against HSV-2. Of note, while the effect was lost against IV in tissue culture models of human airway epithelia, the antiviral activity was confirmed in this relevant model for SARS-CoV-2 Delta. Our results suggest that stilbene dimer derivatives are good candidate models for the treatment of enveloped virus infections.</p> Broad-spectrum antiviral Influenza virus SARS-CoV-2 Stilbene dimer derivatives Virucidal Dewey 615 Dewey 616 Swiss National Science Foundation Improving natural products chemical biodiversity for drug discovery by fungal secretome assisted biotransformation 182438 CH Projects 54 Département de microbiologie et médecine moléculaire 21B 31 Section des sciences pharmaceutiques 17 false 931 Identification des facteurs clés impliqués dans la pathogénèse des rhinovirus et entérovirus 953 882 Phytochimie et produits naturels bioactifs Biomedicine & pharmacotherapy 163 37ff3de8-d082-4f6f-8d8a-24d97acac7f1 Article (Published version) Public 1-s2.0-S0753332223006157-main.pdf 4815663 application/pdf CC BY-NC-ND-4.0 ab7dfd706dfdd2d9630e3221f188a4c5faa91e23c5c112726a5b483503117558 25c8011b-38bb-4acc-b78a-8c8d5f22c78b Supplemental data Public 1-s2.0-S0753332223006157-mmc1.docx 1341426 application/vnd.openxmlformats-officedocument.wordprocessingml.document 09218bca661689fff891e9117020faa114c47ceb2c9266a71a5890bf806a95a4 Vignette Public 1-s2.0-S0753332223006157-ga1.jpg 94784 openAccess Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire Faculté des sciences / Section des sciences pharmaceutiques

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Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses	Biomedicine & pharmacotherapy			2023	252	99

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