Specificity of quantitative functional brain mapping with arterial spin-labeling for preoperative assessment

Article Article scientifique Article Specificity of quantitative functional brain mapping with arterial spin-labeling for preoperative assessment eng 2023-10-19 2023-11-19 author Iannotti Giannina Rita 0000-0002-1343-257X 791431 Centre d'imagerie bio-médicale (CIBM) author Nadin Isaure 678832 author Ivanova Vladimira 754489 author Tourdot Quentin 0009-0002-3607-5541 972784 author Lascano Agustina Maria 0000-0001-7572-8811 636053 Département des neurosciences cliniques (OTONO) author Momjian Shahan Marc 0000-0002-3886-0159 84022 Département des neurosciences cliniques (OTONO) author Schaller Karl Lothard 658606 Département des neurosciences cliniques (OTONO) author Lövblad Karl-Olof 0000-0003-2768-9779 135154 Département de radiologie et informatique médicale (RADIO) author Grouiller Frédéric 0000-0003-3445-5831 684576 1302-1308 10.3174/ajnr.A8006 37857448 0195-6108 PMC10631521 http://www.ajnr.org/lookup/doi/10.3174/ajnr.A8006 Background and purpose: Arterial spin-labeling is a noninvasive MR imaging technique allowing direct and quantitative measurement of brain perfusion. Arterial spin-labeling is well-established in clinics for investigating the overall cerebral perfusion, but it is still occasionally employed during tasks. The typical contrast for functional MR imaging is blood oxygen level-dependent (BOLD) imaging, whose specificity could be biased in neurologic patients due to altered neurovascular coupling. This work aimed to validate the use of functional ASL as a noninvasive tool for presurgical functional brain mapping. This is achieved by comparing the spatial accuracy of functional ASL with transcranial magnetic stimulation as the criterion standard. Materials and methods: Twenty-eight healthy participants executed a motor task and received a somatosensory stimulation, while BOLD imaging and arterial spin-labeling were acquired simultaneously. Transcranial magnetic stimulation was subsequently used to define hand somatotopy. Results: Functional ASL was found more adjacent to transcranial magnetic stimulation than BOLD imaging, with a significant shift along the inferior-to-superior direction. With respect to BOLD imaging, functional ASL was localized significantly more laterally, anteriorly, and inferiorly during motor tasks and pneumatic stimulation. Conclusions: Our results confirm the specificity of functional ASL in targeting the regional neuronal excitability. Functional ASL could be considered as a valid supplementary technique to BOLD imaging for presurgical mapping when spatial accuracy is crucial for delineating eloquent cortex. Arteries Brain Mapping / methods Brain / blood supply Cerebrovascular Circulation / physiology Humans Magnetic Resonance Imaging / methods Spin Labels Dewey 128.37 Dewey 616.8 Dewey 616.0757 62 Département de radiologie et informatique médicale 227 53 Département de neurosciences fondamentales 21A 61 Département des neurosciences cliniques 226 15 Centre interfacultaire en sciences affectives 0D8 false 470 Ischémie cérébrale et connectivité 801 513 Groupe Schaller Karl Lothard (neurochirurgie) 851 American journal of neuroradiology 44 11 5a510e15-18fe-48ae-aa7a-bfb0d28dd5dc Article (Published version) Public 1302.full.pdf 1753045 application/pdf OA OTHER 1bba450dc8177d74eb47b592d79ca9965bdaedc2225e453f8935cb3af33e8f20 4a96358c-d1da-4777-9df7-0073d93a7da1 Supplemental data Public 0266.pdf 812759 application/pdf 600ba6f92a9e3c106a0e9af48d0c74547d014e7e198f3fb16d40c20f429173f9 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Centres et instituts / Centre interfacultaire en sciences affectives

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Specificity of quantitative functional brain mapping with arterial spin-labeling for preoperative assessment	American journal of neuroradiology			2023	83	119

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Tourdot, Quentin