Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries

Article Article scientifique Revue de la littérature Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries eng 2021-10-29 2021 author Faivre Anna 0000-0002-1752-7533 801532 author Verissimo Thomas 0000-0001-6854-6315 933088 author Auwerx Hannah 960739 author Legouis David 883952 author De Seigneux Matthey Sophie 105798 742072 10.3389/fmed.2021.742072 34778303 2296-858X PMC8585753 https://www.frontiersin.org/articles/10.3389/fmed.2021.742072 Acute and chronic kidney disease are responsible for large healthcare costs worldwide. During injury, kidney metabolism undergoes profound modifications in order to adapt to oxygen and nutrient shortage. Several studies highlighted recently the importance of these metabolic adaptations in acute as well as in chronic phases of renal disease, with a potential deleterious effect on fibrosis progression. Until recently, glucose metabolism in the kidney has been poorly studied, even though the kidney has the capacity to use and produce glucose, depending on the segment of the nephron. During physiology, renal proximal tubular cells use the beta-oxidation of fatty acid to generate large amounts of energy, and can also produce glucose through gluconeogenesis. In acute kidney injury, proximal tubular cells metabolism undergo a metabolic shift, shifting away from beta-oxidation of fatty acids and gluconeogenesis toward glycolysis. In chronic kidney disease, the loss of fatty acid oxidation is also well-described, and data about glucose metabolism are emerging. We here review the modifications of proximal tubular cells glucose metabolism during acute and chronic kidney disease and their potential consequences, as well as the potential therapeutic implications. Acute kidney injury Chronic kidney disease Gluconeogenesis Glycolysis Metabolic shift Dewey 612 Dewey 616 Dewey 617 Sir Jules Thorn Charitable Trust Fondation Centre de Recherches MÃ©dicales Carlos et Elsie de Reuter Swiss National Centre of Competence in Research Kidney Control of Homeostasis Swiss National Science Foundation Alterations of tubular metabolism and chronic kidney disease progression 323530_191224 CH Careers;Academic and research careers (non-professorial);MD-PhD fellowships Swiss National Science Foundation The tubular toxicity of proteinuria in chronic kidney disease progression PP00P3_187186 CH Careers 134 Département de physiologie cellulaire et métabolisme 21C 56 Département de médecine 221 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 897 Insuffisance rénale chronique 941 Frontiers in medicine 8 aea49c83-9931-4936-877d-ce378dc50bb5 Article (Published version) Public Article-scientifique-from-europePmc.pdf 910225 application/pdf CC BY-4.0 openAccess Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries	Frontiers in medicine			2021	308	557

Archive ouverte UNIGE

Auwerx, Hannah