Perinatal arterial ischemic stroke : how informative is the placenta ?

Article Article scientifique Article Perinatal arterial ischemic stroke : how informative is the placenta ? eng 2024-03-19 2024-05 author Hirschel Jessica Division of Neonatal and Intensive Care, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland. 671836 author Barcos Munoz Francisca Mariana 0000-0001-7143-6117 Division of Neonatal and Intensive Care, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland. 871644 Francisca Barcos Munoz author Chalard François Unit of Pediatric Radiology, Department of Radiology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 960282 author Chiodini Florence Therapeutic Tissue Biobank, University Hospitals of Geneva, Geneva, Switzerland. 30216 author Epiney Emmanuela Obstetrics Unit Department of Obstetrics and Gynecology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 850809 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Fluss Joel Victor 0000-0002-6413-162X Pediatric Neurology Unit, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland. 28801 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Rougemont-Pidoux Anne-Laure 0000-0002-1785-792X Division of Clinical Pathology, Diagnostic Department, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. anne-laure.rougemont@hug.ch. 29140 Département de pathologie et immunologie (PATIM) 815-825 10.1007/s00428-024-03780-1 38502326 0945-6317 PMC11106178 https://link.springer.com/article/10.1007/s00428-024-03780-1 Neuroplacentology is an expanding field of interest that addresses the placental influence on fetal and neonatal brain lesions and on further neurodevelopment. The objective of this study was to clarify the link between placental pathology and perinatal arterial ischemic stroke (PAIS). Prior publications have reported different types of perinatal stroke with diverse methodologies precluding firm conclusions. We report here the histological placental findings in a series of 16 neonates with radiologically confirmed PAIS. Findings were grouped into 3 categories of lesions: (1) inflammation, (2) placental and fetal hypoxic lesions, and (3) placentas with a high birthweight/placenta weight ratio. Matched control placentas were compared to the pathological placentas when feasible. The eight term singleton placentas were compared to a series of 20 placentas from a highly controlled amniotic membrane donation program; in three twin pregnancies, the placental portions from the affected twin and unaffected co-twin were compared. Slightly more than half (9/16, 56%) had histopathological features belonging to more than one category, a feature shared by the singleton control placentas (13/20, 65%). More severe and extensive lesions were however observed in the pathological placentas. One case occurring in the context of SARS-CoV-2 placentitis further expands the spectrum of COVID-related perinatal disease. Our study supports the assumption that PAIS can result from various combinations and interplay of maternal and fetal factors and confirms the value of placenta examination. Yet, placental findings must be interpreted with caution given their prevalence in well-designed controls. Amsterdam consensus Crack cocaine Drug abuse Neuroplacentology PAIS SARS-CoV-2 Humans Female Pregnancy Placenta / pathology Ischemic Stroke / pathology Infant, Newborn COVID-19 / pathology COVID-19 / complications Adult Male Dewey 616.0757 Dewey 616.07 Dewey 618 137 Département de pathologie et immunologie 21F 58 Département de pédiatrie, gynécologie et obstétrique 223 62 Département de radiologie et informatique médicale 227 false Virchows Archiv 484 5 f914f55e-96d9-4cf3-b3f9-9a0f7d2db48b Article (Published version) Public Article_scientifique_from_unpaywall.pdf 3580919 application/pdf CC BY-4.0 596c2eeaa7eac7ca3b792488528f979fa942f097abfbec671bcf65fbb7d61df3 7fbfa7f8-6c0c-421e-96f6-76c8cb5e0775 Appendix Public 428_2024_3780_MOESM1_ESM.xlsx 17078 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 4b62aef64d60730aa6ffab7b7d7f19418c819d861f70ca5ee95d805bebc37e8e f372b29d-126b-44fa-9daf-a08588c44e87 Appendix Public 428_2024_3780_MOESM2_ESM.xlsx 10864 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 0a038fdd802783e750fa8010e34ac632a154cffe7d0d8329a0dc58e635872ee6 63332e61-e5a1-4cfb-8c88-a08cc6063ff6 Appendix Public 428_2024_3780_MOESM3_ESM.xlsx 13558 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet 3f04e587cd6e0ebf8a76f2f872e52746e97b9f27673185f8c9f07981ea942436 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Perinatal arterial ischemic stroke : how informative is the placenta ?	Virchows Archiv			2024	83	40

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Chalard, François